Design of Controlled Release System for Paracetamol Based on Modified Lignin
by
Mahboubeh Pishnamazi 1, Hamid Hafizi 1, Saeed Shirazian 1
, Mario Culebras 2, Gavin M. Walker 1 and Maurice N. Collins 2,3,*
Mahboubeh Pishnamazi 1, Hamid Hafizi 1, Saeed Shirazian 1, Mario Culebras 2, Gavin M. Walker 1 and Maurice N. Collins 2,3,*
1
Department of Chemical Sciences, Bernal Institute, Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick, V94 T9PX Limerick, Ireland
2
Stokes Laboratories, Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
3
Health Research Institute, University of Limerick, V94 T9PX Limerick, Ireland
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(6), 1059; https://doi.org/10.3390/polym11061059
Received: 15 April 2019 / Revised: 6 June 2019 / Accepted: 15 June 2019 / Published: 18 June 2019
(This article belongs to the Special Issue Polymers in Biomedical Engineering)
The influence of lignin modification on drug release and pH-dependent releasing behavior of oral solid dosage forms was investigated using three different formulations. The first formulation contains microcrystalline cellulose (MCC 101) as the excipient and paracetamol as the active pharmaceutical ingredient (API). The second formulation includes Alcell lignin and MCC 101 as the excipient and paracetamol, and the third formulation consists of carboxylated Alcell lignin, MCC 101 and paracetamol. Direct compaction was carried out in order to prepare the tablets. Lignin can be readily chemically modified due to the existence of different functional groups in its structure. The focus of this investigation is on lignin carboxylation and its influence on paracetamol control release behavior at varying pH. Results suggest that carboxylated lignin tablets had the highest drug release, which is linked to their faster disintegration and lower tablet hardness.
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Keywords:
lignin; drug release; paracetamol; disintegration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style
Pishnamazi, M.; Hafizi, H.; Shirazian, S.; Culebras, M.; Walker, G.M.; Collins, M.N. Design of Controlled Release System for Paracetamol Based on Modified Lignin. Polymers 2019, 11, 1059.
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