Next Article in Journal
Hydrolyzable Additive-Based Silicone Elastomers: A New Approach for Antifouling Coatings
Next Article in Special Issue
Quaternized Polysulfone Cross-Linked N,N-Dimethyl Chitosan-Based Anion-Conducting Membranes
Previous Article in Journal
The Effect of Multilevel Carbon Reinforcements on the Fire Performance, Conductivity, and Mechanical Properties of Epoxy Composites
Open AccessEditor’s ChoiceArticle

Chitosan-Modified PLGA Nanoparticles for Control-Released Drug Delivery

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China
Author to whom correspondence should be addressed.
Polymers 2019, 11(2), 304;
Received: 22 January 2019 / Revised: 9 February 2019 / Accepted: 9 February 2019 / Published: 12 February 2019
Poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) are well recognized as an ideal drug delivery carrier for their biocompatibility and biodegradability. In order to overcome the disadvantage of drug burst release, chitosan (CS) was used to modify the PLGA nanoparticles. In this work, CS-PLGA nanoparticles with different ratio of CS to PLGA were prepared using high-gravity rotating packed bed (RPB). With the increase of amount of CS, the particle size increased from 132.8 ± 1.5 nm to 172.7 ± 3.2 nm, zeta potential increased from −20.8 ± 1.1 mV to 25.6 ± 0.6 mV, and drug encapsulation efficiency increased from 65.8% to 87.1%. The initial burst release of PLGA NPs reduced after being modified by CS, and the cumulative release was 66.9%, 41.9%, 23.8%, and 14.3%, after 2 h, respectively. The drug release of CS-modified PLGA NPs was faster at pH5.5 than that at pH 7.4. The cellular uptake of CS-modified PLGA NPs increased compared with PLGA NPs, while cell viability was reduced. In conclusion, these results indicated that CS-modified, PTX-loaded PLGA NPs have the advantages of sustained drug release and enhanced drug toxicity, suggesting that CS-modified NPs can be used as carriers of anticancer drugs. View Full-Text
Keywords: chitosan; PLGA nanoparticles; paclitaxel; drug release chitosan; PLGA nanoparticles; paclitaxel; drug release
Show Figures

Graphical abstract

MDPI and ACS Style

Lu, B.; Lv, X.; Le, Y. Chitosan-Modified PLGA Nanoparticles for Control-Released Drug Delivery. Polymers 2019, 11, 304.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop