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Open AccessArticle

Bioresorbable Stent in Anterior Cruciate Ligament Reconstruction

Department of Science, Innovation and Development, Galen-Orthopaedics, 43-150 Bierun, Poland
Department of Physiotherapy, Academy of Physical Education, 40-065 Katowice, Poland
Department of Orthopedics and Traumatology, City Hospital in Zabrze, 41-803 Zabrze, Poland
Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Krakow, Poland
University Center of Veterinary Medicine UJ-UR, University of Agriculture in Krakow, Krakow 30-059, Poland
Institute of Fundamentals of Machinery Design, Faculty of Mechanical Engineering, Silesian University of Technology, 44-100 Gliwice, Poland
Institute of Biomedical Engineering, Faculty of Science and Technology, University of Silesia, 41-205 Sosnowiec, Poland
X-ray Microtomography Lab, Department of Computer Biomedical Systems, Institute of Computer Science, Faculty of Computer and Materials Science, University of Silesia, 41-200 Sosnowiec, Poland
Author to whom correspondence should be addressed.
Polymers 2019, 11(12), 1961;
Received: 18 October 2019 / Revised: 19 November 2019 / Accepted: 25 November 2019 / Published: 29 November 2019
(This article belongs to the Special Issue Biocompatible Polymers)
The exact causes of failure of anterior cruciate ligament (ACL) reconstruction are still unknown. A key to successful ACL reconstruction is the prevention of bone tunnel enlargement (BTE). In this study, a new strategy to improve the outcome of ACL reconstruction was analyzed using a bioresorbable polylactide (PLA) stent as a catalyst for the healing process. The study included 24 sheep with 12 months of age. The animals were randomized to the PLA group (n = 16) and control group (n = 8), subjected to the ACL reconstruction with and without the implantation of the PLA tube, respectively. The sheep were sacrificed 6 or 12 weeks post-procedure, and their knee joints were evaluated by X-ray microcomputed tomography with a 50 μm resolution. While the analysis of tibial and femoral tunnel diameters and volumes demonstrated the presence of BTE in both groups, the enlargement was less evident in the PLA group. Also, the microstructural parameters of the bone adjacent to the tunnels tended to be better in the PLA group. This suggested that the implantation of a bioresorbable PLA tube might facilitate osteointegration of the tendon graft after the ACL reconstruction. The beneficial effects of the stent were likely associated with osteogenic and osteoconductive properties of polylactide.
Keywords: anterior cruciate ligament reconstruction; bone tunnel enlargement; X-ray microtomography; polylactide anterior cruciate ligament reconstruction; bone tunnel enlargement; X-ray microtomography; polylactide
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MDPI and ACS Style

Ficek, K.; Rajca, J.; Stolarz, M.; Stodolak-Zych, E.; Wieczorek, J.; Muzalewska, M.; Wyleżoł, M.; Wróbel, Z.; Binkowski, M.; Błażewicz, S. Bioresorbable Stent in Anterior Cruciate Ligament Reconstruction. Polymers 2019, 11, 1961.

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