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Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

Laboratory of Advanced Materials Chemistry, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam
Key Laboratory of Advanced Materials for Energy and Environmental Applications, Lac Hong University, Bien Hoa 810000, Vietnam
Faculty of Materials Technology, Ho Chi Minh City University of Technology (HCMUT), Vietnam National University–Ho Chi Minh City (VNU–HCM), 268 Ly Thuong Kiet, District 10, Ho Chi Minh City 700000, Vietnam
The Faculty of Pharmacy, Duy Tan University, 03 Quang Trung, Danang 550000, Vietnam
Center of Excellence for Green Energy and Environmental Nanomaterials ([email protected]), Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City 755414, Vietnam
Cambridge Centre for Advanced Research and Education in Singapore (CARES), Campus for Research Excellence and Technological Enterprise (CREATE), 1 Create Way, Singapore 138602, Singapore
Department of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
Authors to whom correspondence should be addressed.
Thang Phan Nguyen and Quang Vinh Nguyen equally contributed to this work.
Polymers 2019, 11(12), 1933;
Received: 1 November 2019 / Revised: 22 November 2019 / Accepted: 22 November 2019 / Published: 24 November 2019
(This article belongs to the Section Biopolymers)
Since it was first discovered, thousands of years ago, silkworm silk has been known to be an abundant biopolymer with a vast range of attractive properties. The utilization of silk fibroin (SF), the main protein of silkworm silk, has not been limited to the textile industry but has been further extended to various high-tech application areas, including biomaterials for drug delivery systems and tissue engineering. The outstanding mechanical properties of SF, including its facile processability, superior biocompatibility, controllable biodegradation, and versatile functionalization have allowed its use for innovative applications. In this review, we describe the structure, composition, general properties, and structure-properties relationship of SF. In addition, the methods used for the fabrication and modification of various materials are briefly addressed. Lastly, recent applications of SF-based materials for small molecule drug delivery, biological drug delivery, gene therapy, wound healing, and bone regeneration are reviewed and our perspectives on future development of these favorable materials are also shared. View Full-Text
Keywords: silk fibroin; drug delivery; biologics delivery; wound healing; bone regeneration silk fibroin; drug delivery; biologics delivery; wound healing; bone regeneration
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Nguyen, T.P.; Nguyen, Q.V.; Nguyen, V.-H.; Le, T.-H.; Huynh, V.Q.N.; Vo, D.-V.N.; Trinh, Q.T.; Kim, S.Y.; Le, Q.V. Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review. Polymers 2019, 11, 1933.

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