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Open AccessArticle

Flat Die Extruded Biocompatible Poly(Lactic Acid) (PLA)/Poly(Butylene Succinate) (PBS) Based Films

1
Department of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy
2
Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), 50121 Florence, Italy
3
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
4
OTOLAB, Azienda Ospedaliero-Universitaria Pisana (AOUP), 56122 Pisa, Italy
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(11), 1857; https://doi.org/10.3390/polym11111857
Received: 24 September 2019 / Revised: 30 October 2019 / Accepted: 6 November 2019 / Published: 11 November 2019
(This article belongs to the Special Issue Eurofillers Polymer Blends)
Biodegradable polymers are promising materials for films and sheets used in many widely diffused applications like packaging, personal care products and sanitary products, where the synergy of high biocompatibility and reduced environmental impact can be particularly significant. Plasticized poly(lactic acid) (PLA)/poly(butylene succinate) (PBS) blend-based films, showing high cytocompatibility and improved flexibility than pure PLA, were prepared by laboratory extrusion and their processability was controlled by the use of a few percent of a commercial melt strength enhancer, based on acrylic copolymers and micro-calcium carbonate. The melt strength enhancer was also found effective in reducing the crystallinity of the films. The process was upscaled by producing flat die extruded films in which elongation at break and tear resistance were improved than pure PLA. The in vitro biocompatibility, investigated through the contact of flat die extruded films with cells, namely, keratinocytes and mesenchymal stromal cells, resulted improved with respect to low density polyethylene (LDPE). Moreover, the PLA-based materials were able to affect immunomodulatory behavior of cells and showed a slight indirect anti-microbial effect. These properties could be exploited in several applications, where the contact with skin and body is relevant. View Full-Text
Keywords: poly(lactic acid); poly(butylene succinate); flat die extrusion; biocompatibility poly(lactic acid); poly(butylene succinate); flat die extrusion; biocompatibility
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Gigante, V.; Coltelli, M.-B.; Vannozzi, A.; Panariello, L.; Fusco, A.; Trombi, L.; Donnarumma, G.; Danti, S.; Lazzeri, A. Flat Die Extruded Biocompatible Poly(Lactic Acid) (PLA)/Poly(Butylene Succinate) (PBS) Based Films. Polymers 2019, 11, 1857.

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