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Green-Based Antimicrobial Hydrogels Prepared from Bagasse Cellulose as 3D-Scaffolds for Wound Dressing

Guangxi Key Lab of Petrochemical Resource Processing and Process Intensification Tech., School of Chemistry and Chemical Eng., Guangxi University, Nanning 530004, China
Department of Environmental Science and Engineering, North China Electric Power University, Baoding 071003, China
College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535006, China
Author to whom correspondence should be addressed.
Polymers 2019, 11(11), 1846;
Received: 2 October 2019 / Revised: 20 October 2019 / Accepted: 24 October 2019 / Published: 8 November 2019
(This article belongs to the Special Issue Antimicrobial Polymers II)
Developing the ideal biomaterials for wound dressing still remains challenging nowadays due to the non-biodegradable features and the lack of antimicrobial activity of conventional synthetic polymer-based dressing materials. To tackle those problems, a novel and green-based antimicrobial hydrogel dressing was synthesized in this work via modifying sugarcane bagasse cellulose with guanidine-based polymer, followed by crosslinking antimicrobial-modified cellulose with unmodified one at various ratios. The resulting hydrogels were comprehensively characterized with swelling measurements, compression test, Fourier transform infrared spectroscopy, and scanning electron microscopy. The results indicated that the dressing possessed the degree of swelling up to 2000% and the compress strength as high as 31.39 Kpa, at 8:2 ratio of pristine cellulose to modified cellulose. The antibacterial activities of the dressing against E. coli were assessed using both shaking flask and ring diffusion methods. The results demonstrated that the dressings were highly effective in deactivating bacterium without leaching effect. Moreover, these hydrogels are biocompatible with live cell viability responses of (NIH3T3) cells above 76% and are very promising as wound dressing. View Full-Text
Keywords: cellulose; guanidine-based polymer; hydrogel dressing; antimicrobial activity cellulose; guanidine-based polymer; hydrogel dressing; antimicrobial activity
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MDPI and ACS Style

Pan, Y.; Zhao, X.; Li, X.; Cai, P. Green-Based Antimicrobial Hydrogels Prepared from Bagasse Cellulose as 3D-Scaffolds for Wound Dressing. Polymers 2019, 11, 1846.

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