Developing the ideal biomaterials for wound dressing still remains challenging nowadays due to the non-biodegradable features and the lack of antimicrobial activity of conventional synthetic polymer-based dressing materials. To tackle those problems, a novel and green-based antimicrobial hydrogel dressing was synthesized in this work via modifying sugarcane bagasse cellulose with guanidine-based polymer, followed by crosslinking antimicrobial-modified cellulose with unmodified one at various ratios. The resulting hydrogels were comprehensively characterized with swelling measurements, compression test, Fourier transform infrared spectroscopy, and scanning electron microscopy. The results indicated that the dressing possessed the degree of swelling up to 2000% and the compress strength as high as 31.39 Kpa, at 8:2 ratio of pristine cellulose to modified cellulose. The antibacterial activities of the dressing against E. coli
were assessed using both shaking flask and ring diffusion methods. The results demonstrated that the dressings were highly effective in deactivating bacterium without leaching effect. Moreover, these hydrogels are biocompatible with live cell viability responses of (NIH3T3) cells above 76% and are very promising as wound dressing.
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