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Polymers 2019, 11(1), 118; https://doi.org/10.3390/polym11010118

Theoretical Modeling of Polymer Translocation: From the Electrohydrodynamics of Short Polymers to the Fluctuating Long Polymers

1
Department of Physics, Bilkent University, Ankara 06800, Turkey
2
School of Nano Science, Institute for Research in Fundamental Sciences (IPM), Tehran 19395-5531, Iran
3
Interdisciplinary Centre for Mathematical Modelling and Department of Mathematical Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
4
Department of Applied Physics and QTF Center of Excellence, Aalto University School of Science, P.O. Box 11000, FI-00076 Aalto, Espoo, Finland
*
Author to whom correspondence should be addressed.
Received: 18 December 2018 / Revised: 7 January 2019 / Accepted: 9 January 2019 / Published: 11 January 2019
(This article belongs to the Special Issue Polymer in Confinement)
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Abstract

The theoretical formulation of driven polymer translocation through nanopores is complicated by the combination of the pore electrohydrodynamics and the nonequilibrium polymer dynamics originating from the conformational polymer fluctuations. In this review, we discuss the modeling of polymer translocation in the distinct regimes of short and long polymers where these two effects decouple. For the case of short polymers where polymer fluctuations are negligible, we present a stiff polymer model including the details of the electrohydrodynamic forces on the translocating molecule. We first show that the electrohydrodynamic theory can accurately characterize the hydrostatic pressure dependence of the polymer translocation velocity and time in pressure-voltage-driven polymer trapping experiments. Then, we discuss the electrostatic correlation mechanisms responsible for the experimentally observed DNA mobility inversion by added multivalent cations in solid-state pores, and the rapid growth of polymer capture rates by added monovalent salt in α -Hemolysin pores. In the opposite regime of long polymers where polymer fluctuations prevail, we review the iso-flux tension propagation (IFTP) theory, which can characterize the translocation dynamics at the level of single segments. The IFTP theory is valid for a variety of polymer translocation and pulling scenarios. We discuss the predictions of the theory for fully flexible and rodlike pore-driven and end-pulled translocation scenarios, where exact analytic results can be derived for the scaling of the translocation time with chain length and driving force. View Full-Text
Keywords: polymer translocation; dielectric membranes; electrostatic interactions; charge screening polymer translocation; dielectric membranes; electrostatic interactions; charge screening
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Buyukdagli, S.; Sarabadani, J.; Ala-Nissila, T. Theoretical Modeling of Polymer Translocation: From the Electrohydrodynamics of Short Polymers to the Fluctuating Long Polymers. Polymers 2019, 11, 118.

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