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Polymers 2018, 10(9), 974; https://doi.org/10.3390/polym10090974

Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers

1
Environmental Safety Group, Korea Institute of Science & Technology Europe GmbH, 66123 Saarbrücken, Germany
2
Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Germany
3
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, B4495 Oxford, UK
*
Author to whom correspondence should be addressed.
Received: 19 April 2018 / Revised: 26 August 2018 / Accepted: 28 August 2018 / Published: 1 September 2018
(This article belongs to the Special Issue Bioactive and Biofunctional Conductive Polymers)
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Abstract

Molecularly imprinted polymers (MIPs) have proven to be particularly effective chemical probes for the molecular recognition of proteins, DNA, and viruses. Here, we started from a filamentous bacteriophage to synthesize a multi-functionalized MIP for detecting the acidic pharmaceutic clofibric acid (CA) as a chemical pollutant. Adsorption and quartz crystal microbalance with dissipation monitoring experiments showed that the phage-functionalized MIP had a good binding affinity for CA, compared with the non-imprinted polymer and MIP. In addition, the reusability of the phage-functionalized MIP was demonstrated for at least five repeated cycles, without significant loss in the binding activity. The results indicate that the exposed amino acids of the phage, together with the polymer matrix, create functional binding cavities that provide higher affinity to acidic pharmaceutical compounds. View Full-Text
Keywords: molecularly imprinted polymer; polypyrrole; filamentous bacteriophage; clofibric acid; self-assembly; virus; electrochemical polymerization; microbalance sensor molecularly imprinted polymer; polypyrrole; filamentous bacteriophage; clofibric acid; self-assembly; virus; electrochemical polymerization; microbalance sensor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Baek, I.-H.; Han, H.-S.; Baik, S.; Helms, V.; Kim, Y. Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers. Polymers 2018, 10, 974.

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