Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Formulation of Nanoemulsions (NE)
2.3. Preparation of NE(κ-CAR/CS)x Nanocapsules by Layer-By-Layer Self-Assembly
2.4. Characterization of NE and NE(κ-CAR/CS)x Nanocapsules
2.4.1. Particle-Size and Zeta Potential Measurements
2.4.2. Morphological Analyses
2.4.3. Fourier Transform Infrared (FTIR) Spectroscopy
2.5. Drug Release
2.5.1. Encapsulation Efficiency
2.5.2. In Vitro Drug Release
2.6. Mathematical Modelling
2.6.1. Korsmeyer-Peppas Model
2.6.2. Higuchi Model
2.6.3. First Order Kinetic Model
2.6.4. Zero Order Kinetic Model
2.7. Statistical Analysis
3. Results and Discussion
3.1. Characterization of NE and NE(κ-CAR/CS)x Oil-Core Nanocapsules
3.1.1. Particle Size
3.1.2. Zeta Potential Measurements
3.1.3. Morphological Analyses
3.1.4. X-ray Energy Dispersive Spectrometry (XEDS) Analysis
3.1.5. Fourier Transform Infrared (FTIR) Spectroscopy
3.2. In Vitro Drug Release
Mathematical Modelling
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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System | Korsmeyer-Peppas | Higuchi | First Order | Zero Order | |||||
---|---|---|---|---|---|---|---|---|---|
kKP × 102 (min−n) | n | R2 | kH × 102 (min−0.5) | R2 | k1 × 102 (min−1) | R2 | k0 × 102 (min−1) | R2 | |
NE | 7.5 ± 0.4 | 0.56 ± 0.02 | 0.9883 | 9.2 ± 0.1 | 0.9801 | 2.6 ± 0.1 | 0.9177 | 1.7 ± 0.1 | 0.6898 |
NE-κ-CAR | 3.8 ± 0.1 | 0.74 ± 0.01 | 0.9754 | 8.4 ± 0.1 | 0.8973 | 2.3 ± 0.1 | 0.9879 | 1.6 ± 0.1 | 0.9190 |
NE(κ-CAR/CS)1 | 2.2 ± 0.1 | 0.89 ± 0.01 | 0.9760 | 7.9 ± 0.3 | 0.8271 | 2.1 ± 0.1 | 0.9791 | 1.5 ± 0.1 | 0.9729 |
NE(κ-CAR/CS)1-κ-CAR | 1.4 ± 0.2 | 0.97 ± 0.02 | 0.9877 | 7.1 ± 0.1 | 0.8006 | 1.7 ± 0.1 | 0.9717 | 1.3 ± 0.1 | 0.9893 |
NE(κ-CAR/CS)2 | 1.0 ± 0.1 | 0.99 ± 0.04 | 0.9748 | 6.2 ± 0.5 | 0.7648 | Na | - | 1.0 ± 0.1 | 0.9793 |
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Rochín-Wong, S.; Rosas-Durazo, A.; Zavala-Rivera, P.; Maldonado, A.; Martínez-Barbosa, M.E.; Vélaz, I.; Tánori, J. Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers. Polymers 2018, 10, 760. https://doi.org/10.3390/polym10070760
Rochín-Wong S, Rosas-Durazo A, Zavala-Rivera P, Maldonado A, Martínez-Barbosa ME, Vélaz I, Tánori J. Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers. Polymers. 2018; 10(7):760. https://doi.org/10.3390/polym10070760
Chicago/Turabian StyleRochín-Wong, Sarai, Aarón Rosas-Durazo, Paul Zavala-Rivera, Amir Maldonado, María Elisa Martínez-Barbosa, Itziar Vélaz, and Judith Tánori. 2018. "Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers" Polymers 10, no. 7: 760. https://doi.org/10.3390/polym10070760
APA StyleRochín-Wong, S., Rosas-Durazo, A., Zavala-Rivera, P., Maldonado, A., Martínez-Barbosa, M. E., Vélaz, I., & Tánori, J. (2018). Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers. Polymers, 10(7), 760. https://doi.org/10.3390/polym10070760