Next Article in Journal
Chirality Construction from Preferred π-π Stacks of Achiral Azobenzene Units in Polymer: Chiral Induction, Transfer and Memory
Next Article in Special Issue
Synthesis of Poly(ε-caprolactone)-Based Miktoarm Star Copolymers through ROP, SA ATRC, and ATRP
Previous Article in Journal
Highly Graphitized Carbon Coating on SiO with a π–π Stacking Precursor Polymer for High Performance Lithium-Ion Batteries
Previous Article in Special Issue
Reconfigurable Shape Memory and Self-Welding Properties of Epoxy Phenolic Novolac/Cashew Nut Shell Liquid Composites Reinforced with Carbon Nanotubes
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessCommunication
Polymers 2018, 10(6), 611;

Synthetic Glycopolypeptide Micelle for Targeted Drug Delivery to Hepatic Carcinoma

1,* and 2,*
Department of Chemistry, Changchun University of Science and Technology, Changchun 130022, China
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 14 May 2018 / Accepted: 22 May 2018 / Published: 4 June 2018
(This article belongs to the Special Issue Smart Polymers)
Full-Text   |   PDF [4241 KB, uploaded 4 June 2018]   |  


The targeted delivery of chemotherapy drugs to tumor lesions is a major challenge for the treatment of tumors. Up until now, various polymeric nanoparticles have been explored to improve the targetability of these therapeutic drugs through passive or active targeting processes. In the design and construction of polymer nanoparticles, glycopolypeptide has shown great potential owing to its excellent targeting ability and biocompatibility. In order to enhance the antitumor effect of doxorubicin (DOX), a glycopolypeptide-based micelle (GPM) modified by α-lactose (Lac) was synthesized for targeted treatment of hepatoma. The DOX-loaded GPM (i.e., GPM/DOX) could significantly target human hepatoma (HepG2) cells and further inhibit their proliferation in vitro. Additionally, GPM/DOX exhibited a much higher drug accumulation in tumor tissue and a stronger antitumor effect in vivo than free DOX. The above results revealed that this drug delivery system provides a promising platform for the targeting therapy of hepatic cancer. View Full-Text
Keywords: glycopolypeptide; micelle; targeting chemotherapy; controlled drug release; hepatic carcinoma glycopolypeptide; micelle; targeting chemotherapy; controlled drug release; hepatic carcinoma

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Li, P.; Han, J.; Li, D.; Chen, J.; Wang, W.; Xu, W. Synthetic Glycopolypeptide Micelle for Targeted Drug Delivery to Hepatic Carcinoma. Polymers 2018, 10, 611.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top