Next Article in Journal
Thermal Stability of Allyl-Functional Phthalonitriles-Containing Benzoxazine/Bismaleimide Copolymers and Their Improved Mechanical Properties
Next Article in Special Issue
pH-Responsive Hybrid Hydrogels as Antibacterial and Drug Delivery Systems
Previous Article in Journal
Rheology, Non-Isothermal Crystallization Behavior, Mechanical and Thermal Properties of PMMA-Modified Carbon Fiber-Reinforced Poly(Ethylene Terephthalate) Composites
Previous Article in Special Issue
Soy-Based Soft Matrices for Encapsulation and Delivery of Hydrophilic Compounds
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview

Dendritic Polyglycerol Sulfate for Therapy and Diagnostics

Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
Author to whom correspondence should be addressed.
Polymers 2018, 10(6), 595;
Received: 25 April 2018 / Revised: 22 May 2018 / Accepted: 26 May 2018 / Published: 29 May 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)
PDF [1317 KB, uploaded 29 May 2018]


Dendritic polyglycerol sulfate (dPGS) has originally been investigated as an anticoagulant to potentially substitute for the natural glycosaminoglycan heparin. Compared to unfractionated heparin, dPGS possesses lower anticoagulant activity but a much higher anticomplementary effect. Since coagulation, complement activation, and inflammation are often present in the pathophysiology of numerous diseases, dPGS polymers with both anticoagulant and anticomplementary activities represent promising candidates for the development of polymeric drugs of nanosized architecture. In this review, we describe the nanomedical applications of dPGS based on its anti-inflammatory activity. Furthermore, the application of dPGS as a carrier molecule for diagnostic molecules and therapeutic drugs is reviewed, based on the ability to target tumors and localize in tumor cells. Finally, the application of dPGS for inhibition of virus infections is described. View Full-Text
Keywords: dendritic polyglycerol; heparin; inflammation; targeting dendritic polyglycerol; heparin; inflammation; targeting

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Rades, N.; Licha, K.; Haag, R. Dendritic Polyglycerol Sulfate for Therapy and Diagnostics. Polymers 2018, 10, 595.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top