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Polymers 2018, 10(5), 493; https://doi.org/10.3390/polym10050493

Controlled Levofloxacin Release and Antibacterial Properties of β-Cyclodextrins-Grafted Polypropylene Mesh Devices for Hernia Repair

1
Key Laboratory of Textile Science and Technology of Ministry of Education, College of Textiles, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, China
2
Department of Textile Engineering, Mehran University of Engineering and Technology Jamshoro, Sindh 76062, Pakistan
3
College of Textiles and Fashion, Xingjiang University, 666 Sheng Li Road, Tian Shan, Wulumuqi 830046, China
4
Division of Textiles and Clothing, University of California, Davis, CA 95616, USA
*
Authors to whom correspondence should be addressed.
Received: 31 March 2018 / Revised: 29 April 2018 / Accepted: 1 May 2018 / Published: 3 May 2018
(This article belongs to the Special Issue Antimicrobial Polymers)
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Abstract

Mesh infection is a major complication of hernia repair. After knitted mesh implantation, bacteria can grow within textile structures causing infection. In this work, polypropylene (PP) mesh devices were two-step grafted with hexamethylene diisocyanate (HDI) and β–cyclodexrins (CD) and then loaded with suitable antimicrobial levofloxacin HCL for hernia mesh-infection prevention. First, oxygen plasma was able to create surface roughness, then HDI was successfully grafted onto PP fiber surfaces. Afterwards, CD was covalently grafted onto the HDI treated PP meshes, and levofloxacin HCL (LVFX) was loaded into the CD cavity of the modified meshes. The modified devices were evaluated for sustained antibiotic properties and drug-release profiles in a phosphate buffer, and sustained drug release was observed between interfaces of meshes and aqueous environment. The antibiotic-loaded PP mesh samples demonstrated sustained antibacterial properties for 7 and 10 days, respectively, against both Gram-negative and Gram-positive bacteria. The CD-captured levofloxacin HCL showed burst release after 6 h but later exhibited sustained release for the next 48 h. Among all samples, the modified mesh LVFX-6 was more stable and showed more sustained drug release and could be employed in future clinical applications. View Full-Text
Keywords: drug release; levofloxacin antimicrobial; β-Cyclodextrin grafting; polypropylene; hernia repair drug release; levofloxacin antimicrobial; β-Cyclodextrin grafting; polypropylene; hernia repair
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sanbhal, N.; Saitaer, X.; Li, Y.; Mao, Y.; Zou, T.; Sun, G.; Wang, L. Controlled Levofloxacin Release and Antibacterial Properties of β-Cyclodextrins-Grafted Polypropylene Mesh Devices for Hernia Repair. Polymers 2018, 10, 493.

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