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Polymers 2018, 10(5), 476;

New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003, China
Basic Medical Experimental Teaching Center, School of Basic Medical Science, Guizhou Medical University, Guiyang 550025, China
The State Key Laboratories of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Co. Ltd., Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, China
School of Pharmaceutical Science, Guizhou Medical University, Guiyang 550025, China
Authors to whom correspondence should be addressed.
Received: 19 March 2018 / Revised: 22 April 2018 / Accepted: 23 April 2018 / Published: 27 April 2018
(This article belongs to the Special Issue Nanostructured Polymers and Nanocomposites)
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Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8–based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system. View Full-Text
Keywords: polydopamine; ZIF-8; Zinc-releasing; anticancer activity polydopamine; ZIF-8; Zinc-releasing; anticancer activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ran, J.; Wang, C.; Zhang, J.; Wang, W.; Xiao, L.; Jia, S.; Wang, Z.; Wu, W.; Xiao, J.; Wu, X. New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity. Polymers 2018, 10, 476.

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