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Open AccessArticle

α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine

by Sa Liu 1,2, Chunting Zhong 1,2, Weiwei Wang 1,2, Yongguang Jia 1,2, Lin Wang 1,2 and Li Ren 1,2,*
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
Author to whom correspondence should be addressed.
Polymers 2018, 10(2), 190;
Received: 30 November 2017 / Revised: 30 January 2018 / Accepted: 5 February 2018 / Published: 14 February 2018
(This article belongs to the Special Issue Host-Guest Polymer Complexes)
As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). View Full-Text
Keywords: polyrotaxane; silver sulfadiazine; mechanism; antibacterial polyrotaxane; silver sulfadiazine; mechanism; antibacterial
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MDPI and ACS Style

Liu, S.; Zhong, C.; Wang, W.; Jia, Y.; Wang, L.; Ren, L. α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine. Polymers 2018, 10, 190.

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