α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine
AbstractAs a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). View Full-Text
- Supplementary File 1:
Supplementary (PDF, 552 KB)
Share & Cite This Article
Liu, S.; Zhong, C.; Wang, W.; Jia, Y.; Wang, L.; Ren, L. α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine. Polymers 2018, 10, 190.
Liu S, Zhong C, Wang W, Jia Y, Wang L, Ren L. α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine. Polymers. 2018; 10(2):190.Chicago/Turabian Style
Liu, Sa; Zhong, Chunting; Wang, Weiwei; Jia, Yongguang; Wang, Lin; Ren, Li. 2018. "α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine." Polymers 10, no. 2: 190.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.