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Polymers 2018, 10(1), 58; https://doi.org/10.3390/polym10010058

Preparation and Characterization of Antibacterial Polypropylene Meshes with Covalently Incorporated β-Cyclodextrins and Captured Antimicrobial Agent for Hernia Repair

1
Key Laboratory of Textile Science and Technology of Ministry of Education, Room 4023, College of Textiles, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, China
2
Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro 76062, Sindh, Pakistan
3
Division of Textiles and Clothing, University of California, Davis, CA 95616, USA
*
Authors to whom correspondence should be addressed.
Received: 28 November 2017 / Revised: 20 December 2017 / Accepted: 5 January 2018 / Published: 11 January 2018
(This article belongs to the Special Issue Host-Guest Polymer Complexes)
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Abstract

Polypropylene (PP) light weight meshes are commonly used as hernioplasty implants. Nevertheless, the growth of bacteria within textile knitted mesh intersections can occur after surgical mesh implantation, causing infections. Thus, bacterial reproduction has to be stopped in the very early stage of mesh implantation. Herein, novel antimicrobial PP meshes grafted with β-CD and complexes with triclosan were prepared for mesh infection prevention. Initially, PP mesh surfaces were functionalized with suitable cold oxygen plasma. Then, hexamethylene diisocyanate (HDI) was successfully grafted on the plasma-activated PP surfaces. Afterwards, β-CD was connected with the already HDI reacted PP meshes and triclosan, serving as a model antimicrobial agent, was loaded into the cyclodextrin (CD) cavity for desired antibacterial functions. The hydrophobic interior and hydrophilic exterior of β-CD are well suited to form complexes with hydrophobic host guest molecules. Thus, the prepared PP mesh samples, CD-TCL-2 and CD-TCL-6 demonstrated excellent antibacterial properties against Staphylococcus aureus and Escherichia coli that were sustained up to 11 and 13 days, respectively. The surfaces of chemically modified PP meshes showed dramatically reduced water contact angles. Moreover, X-ray diffractometer (XRD), differential scanning calorimeter (DSC), and Thermogravimetric (TGA) evidenced that there was no significant effect of grafted hexamethylene diisocyanate (HDI) and CD on the structural and thermal properties of the PP meshes. View Full-Text
Keywords: antibacterial meshes; guest molecule; cyclodextrin grafting; polypropylene; oxygen plasma antibacterial meshes; guest molecule; cyclodextrin grafting; polypropylene; oxygen plasma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sanbhal, N.; Mao, Y.; Sun, G.; Li, Y.; Peerzada, M.; Wang, L. Preparation and Characterization of Antibacterial Polypropylene Meshes with Covalently Incorporated β-Cyclodextrins and Captured Antimicrobial Agent for Hernia Repair. Polymers 2018, 10, 58.

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