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Polymers 2018, 10(11), 1272; https://doi.org/10.3390/polym10111272

ZnO Quantum Dots Modified by pH-Activated Charge-Reversal Polymer for Tumor Targeted Drug Delivery

1
Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China
2
Laboratory for New Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China
3
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
*
Author to whom correspondence should be addressed.
Received: 25 October 2018 / Revised: 9 November 2018 / Accepted: 12 November 2018 / Published: 15 November 2018
(This article belongs to the Special Issue Functionally Responsive Polymeric Materials II)
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Abstract

In this paper, we reported a pH responsive nano drug delivery system (NDDS) based on ZnO quantum dots (QDs) for controlled release of drugs. Zwitterionic poly(carboxybetaine methacrylate) (PCBMA) and poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) were introduced to modify ZnO QDs, which can help enhance water stability, increase blood circulation time, and promote endocytosis. After tuning of PCBMA/PDMAEMA ratios, the [email protected](CBMA-co-DMAEMA) nanoplatform shows a sensitive switch from strong protein adsorption resistance (with negatively charged surface) at physiological pH to strong adhesion to tumor cell membranes (with positively charged surface) at the slightly acidic extracellular pH of tumors. Anti-cancer drug, Doxorubicin (DOX), molecules were demonstrated to be successfully loaded to [email protected](CBMA-co-DMAEMA) with a relatively large drug loading content (24.6%). In addition, [email protected](CBMA-co-DMAEMA) loaded with DOX can achieve lysosomal acid degradation and release of DOX after endocytosis by tumor cells, resulting in synergistic treatment of cancer, which is attributed to a combination of the anticancer effect of Zn2+ and DOX. View Full-Text
Keywords: Zinc oxide quantum dots (ZnO QDs); poly(carboxybetaine methacry late) (PCBMA); poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA); drug delivery Zinc oxide quantum dots (ZnO QDs); poly(carboxybetaine methacry late) (PCBMA); poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA); drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, Y.; He, L.; Yu, B.; Chen, Y.; Shen, Y.; Cong, H. ZnO Quantum Dots Modified by pH-Activated Charge-Reversal Polymer for Tumor Targeted Drug Delivery. Polymers 2018, 10, 1272.

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