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Continuous Generation of Millimeter-Sized Glycine Crystals in Non-Seeded Millifluidic Slug Flow

1
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, USA
2
Boehringer Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road, Ridgefield, CT 06877, USA
*
Author to whom correspondence should be addressed.
Crystals 2019, 9(8), 412; https://doi.org/10.3390/cryst9080412
Received: 4 July 2019 / Revised: 29 July 2019 / Accepted: 2 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Anti-Solvent Crystallization)
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Abstract

Millimeter-sized α-glycine crystals were generated from continuous non-seeded cooling crystallization in slug flow. The crystallization process is composed of three steps in sequence: slug formation, crash-cooling nucleation, and growth. Stable uniform slugs of three different aspect ratios (slug length/tubing inner diameter) were formed, by adjusting the flow rates of both the solution and air streams. Besides supersaturation, the slug aspect ratio can also affect primary nucleation outcome. Stable slug flow can accommodate a relative supersaturation (C/C*) of up to 1.5 without secondary nucleation. Large glycine crystals can grow to millimeter size within 10 min, inside millimeter-sized slugs without reducing the slug quality. View Full-Text
Keywords: continuous crystallization; cooling crystallization; nucleation; crystal growth rate; slug flow; glycine continuous crystallization; cooling crystallization; nucleation; crystal growth rate; slug flow; glycine
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Mou, M.; Li, H.; Yang, B.-S.; Jiang, M. Continuous Generation of Millimeter-Sized Glycine Crystals in Non-Seeded Millifluidic Slug Flow. Crystals 2019, 9, 412.

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