Next Article in Journal
Layered Double Hydroxides: A Toolbox for Chemistry and Biology
Next Article in Special Issue
Synthesis, X-Ray Crystal Structure, Hirshfeld Surface Analysis, and Molecular Docking Study of Novel Hepatitis B (HBV) Inhibitor: 8-Fluoro-5-(4-fluorobenzyl)-3-(2-methoxybenzyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one
Previous Article in Journal
Fe Melting Transition: Electrical Resistivity, Thermal Conductivity, and Heat Flow at the Inner Core Boundaries of Mercury and Ganymede
Previous Article in Special Issue
Preparation of Theophylline-Benzoic Acid Cocrystal and On-Line Monitoring of Cocrystallization Process in Solution by Raman Spectroscopy
Open AccessArticle

Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal

School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Qingdao Institute for Food and Drug Control, Qingdao 266071, China
School of Pharmacy, Qingdao University, Qingdao 266071, China
Author to whom correspondence should be addressed.
Crystals 2019, 9(7), 360;
Received: 15 May 2019 / Revised: 8 July 2019 / Accepted: 10 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Pharmaceutical Crystals)
PDF [3012 KB, uploaded 22 July 2019]


A novel cocrystal of the potent H2 receptor antagonist famotidine (FMT) was synthesized with malonic acid (MAL) to enhance its solubility. The cocrystal structure was characterized by X-ray single crystal diffraction, and the asymmetry unit contains one FMT and one MAL connected via intermolecular hydrogen bonds. The crystal structure is monoclinic with a P21/n space group and unit cell parameters a = 7.0748 (3) Å, b = 26.6502 (9) Å, c = 9.9823 (4) Å, α = 90, β = 104.2228 (12), γ = 90, V = 1824.42 (12) Å3, and Z = 4. The cocrystal had unique thermal, spectroscopic, and powder X-ray diffraction (PXRD) properties that differed from FMT. The solubility of the famotidine-malonic acid cocrystal (FMT-MAL) was 4.2-fold higher than FMT; the FAM-MAL had no change in FMT stability at high temperature, high humidity, or with illumination. View Full-Text
Keywords: cocrystal; famotidine; malonic acid; crystal structure; solubility cocrystal; famotidine; malonic acid; crystal structure; solubility

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Zhang, Y.; Yang, Z.; Zhang, S.; Zhou, X. Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal. Crystals 2019, 9, 360.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Crystals EISSN 2073-4352 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top