Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal
AbstractA novel cocrystal of the potent H2 receptor antagonist famotidine (FMT) was synthesized with malonic acid (MAL) to enhance its solubility. The cocrystal structure was characterized by X-ray single crystal diffraction, and the asymmetry unit contains one FMT and one MAL connected via intermolecular hydrogen bonds. The crystal structure is monoclinic with a P21/n space group and unit cell parameters a = 7.0748 (3) Å, b = 26.6502 (9) Å, c = 9.9823 (4) Å, α = 90, β = 104.2228 (12), γ = 90, V = 1824.42 (12) Å3, and Z = 4. The cocrystal had unique thermal, spectroscopic, and powder X-ray diffraction (PXRD) properties that differed from FMT. The solubility of the famotidine-malonic acid cocrystal (FMT-MAL) was 4.2-fold higher than FMT; the FAM-MAL had no change in FMT stability at high temperature, high humidity, or with illumination. View Full-Text
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Zhang, Y.; Yang, Z.; Zhang, S.; Zhou, X. Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal. Crystals 2019, 9, 360.
Zhang Y, Yang Z, Zhang S, Zhou X. Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal. Crystals. 2019; 9(7):360.Chicago/Turabian Style
Zhang, Yan; Yang, Zhao; Zhang, Shuaihua; Zhou, Xingtong. 2019. "Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal." Crystals 9, no. 7: 360.
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