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Synthesis and Biological Evaluations of a Novel Oxidovanadium(IV) Adenosine Monophosphate Complex as Anti-Diabetic Agent

1
Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
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Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo 12622-Dokki, Egypt
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Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
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Department of Chemistry, College of Science, Princess NourahBint Abdulrahman University, Riyadh 11671, Saudi Arabia
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Nutrition and Food Sciences Department, Princess NourahBint Abdulrahman University, Riyadh 11671, Saudi Arabia
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Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt
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Department of Chemistry, Faculty of Science, Port Said, Port Said University, Port Said 42526, Egypt
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Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Crystals 2019, 9(4), 208; https://doi.org/10.3390/cryst9040208
Received: 5 March 2019 / Revised: 3 April 2019 / Accepted: 9 April 2019 / Published: 15 April 2019
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Abstract

In the present study, a novel [(AMP)(VO)(H2O)2] complex was formed through chemical reactions between oxidovanadium(IV)sulfate and adenosine monophosphate. This complex was characterized using various analyses, including microanalytical, molar conductivity, spectroscopic (solid reflectance and FTIR), magnetic susceptibility, thermogravimetric (TGA), X-ray powder diffraction (XRD), and scanning (SEM) and transmission (TEM) electron microscopy. The in vivo antidiabetic activity of the oxidovanadium(IV) complex was determined using streptozotocin-induced rats. The results suggested that the synthesized complex can be used as an antidiabetic agent based on the observed biochemical effects. View Full-Text
Keywords: diabetes; oxidovanadium(IV) sulfate; adenosine monophosphate; metal ions; streptozotocin; complex diabetes; oxidovanadium(IV) sulfate; adenosine monophosphate; metal ions; streptozotocin; complex
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Naglah, A.M.; Al-Omar, M.A.; Bhat, M.A.; Al-Wasidi, A.S.; Alsuhaibani, A.M.A.; El-Didamony, A.M.; Hassan, N.; Abo Taleb, S.; Refat, M.S. Synthesis and Biological Evaluations of a Novel Oxidovanadium(IV) Adenosine Monophosphate Complex as Anti-Diabetic Agent. Crystals 2019, 9, 208.

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