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Article

A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing

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Laboratory for Electron Spin Spectroscopy, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
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Department of Occupational Safety and Health, Fire and Radiation Protection Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
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Department of Urology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
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Laboratory for Atomic Physics, Vinča Institute of Nuclear Sciences—National Institute of the Republic of Serbia, Belgrade University, Mike Petrovića Alasa 12–14, Vinča, 11351 Belgrade, Serbia
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FR CERAMATHS Département Matériaux et Procédés, Université Polytechnique Hauts-de-France (UPHF), 59600 Maubeuge, France
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Laboratory for Synthesis of New Materials, Division of Materials Chemistry, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
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Laboratory for Precipitation Processes, Division of Materials Chemistry, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
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Laboratory for Biocolloids and Surface Chemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Jaime Gómez Morales
Crystals 2022, 12(2), 297; https://doi.org/10.3390/cryst12020297
Received: 3 February 2022 / Revised: 17 February 2022 / Accepted: 18 February 2022 / Published: 19 February 2022
To assess the application potential of novel biomaterials, their behaviour in model media and upon sterilization should be investigated, as well as the stability related to their storage conditions. Such data are lacking for Mg-substituted HAP (Mg-HAP). Therefore, the changes in the local structure of non-substituted and Mg-HAP after irradiation and immersion in corrected simulated fluid and saline solution for 28 days were followed by electron paramagnetic resonance (EPR) spectroscopy for the first time. To better understand the stability of radical species induced by sterilization, EPR spectra of samples kept for 2 h at temperatures up to 373 K were recorded to provide an insight into the stability of the sample storage conditions by the accelerated aging method. Samples were characterized by PXRD, FTIR, SEM, EDS, AAS and TGA. Results confirmed that irradiation does not induce changes in the composition or the structure of any of the investigated materials. Fading or the complete disappearance of radical signals in the EPR spectra after immersion in both media was accompanied by the disappearance of other phases formed as a minor byproduct in the synthesis of substituted HAP, as confirmed by PXRD and FTIR analysis. Obtained results confirm the great potential of Mg-HAPs for biomedical applications, although closer attention should be given to the processes related to sample storage stability at different temperatures. View Full-Text
Keywords: ion-substituted hydroxyapatite; magnesium; electron paramagnetic spectroscopy; simulated body fluid; saline ion-substituted hydroxyapatite; magnesium; electron paramagnetic spectroscopy; simulated body fluid; saline
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MDPI and ACS Style

Vidotto, M.; Grego, T.; Petrović, B.; Somers, N.; Antonić Jelić, T.; Kralj, D.; Matijaković Mlinarić, N.; Leriche, A.; Dutour Sikirić, M.; Erceg, I.; Maltar-Strmečki, N. A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing. Crystals 2022, 12, 297. https://doi.org/10.3390/cryst12020297

AMA Style

Vidotto M, Grego T, Petrović B, Somers N, Antonić Jelić T, Kralj D, Matijaković Mlinarić N, Leriche A, Dutour Sikirić M, Erceg I, Maltar-Strmečki N. A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing. Crystals. 2022; 12(2):297. https://doi.org/10.3390/cryst12020297

Chicago/Turabian Style

Vidotto, Monica, Timor Grego, Božana Petrović, Nicolas Somers, Tatjana Antonić Jelić, Damir Kralj, Nives Matijaković Mlinarić, Anne Leriche, Maja Dutour Sikirić, Ina Erceg, and Nadica Maltar-Strmečki. 2022. "A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing" Crystals 12, no. 2: 297. https://doi.org/10.3390/cryst12020297

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