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Article

A Novel Shadowgraphic Inline Measurement Technique for Image-Based Crystal Size Distribution Analysis

1
Chair of Separation Science and Technology, TU Kaiserslautern, Gottlieb-Daimler-Straße, 67663 Kaiserslautern, Germany
2
Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstraße 1, 39106 Magdeburg, Germany
3
Sulzer Chemtech Ltd., Gewerbestraße 28, 4123 Allschwil, Switzerland
*
Author to whom correspondence should be addressed.
Crystals 2020, 10(9), 740; https://doi.org/10.3390/cryst10090740
Received: 30 July 2020 / Revised: 17 August 2020 / Accepted: 19 August 2020 / Published: 21 August 2020
(This article belongs to the Special Issue Advances in Industrial Crystallization)
A novel shadowgraphic inline probe to measure crystal size distributions (CSD), based on acquired greyscale images, is evaluated in terms of elevated temperatures and fragile crystals, and compared to well-established, alternative online and offline measurement techniques, i.e., sieving analysis and online microscopy. Additionally, the operation limits, with respect to temperature, supersaturation, suspension, and optical density, are investigated. Two different substance systems, potassium dihydrogen phosphate (prisms) and thiamine hydrochloride (needles), are crystallized for this purpose at 25 L scale. Crystal phases of the well-known KH2PO4/H2O system are measured continuously by the inline probe and in a bypass by the online microscope during cooling crystallizations. Both measurement techniques show similar results with respect to the crystal size distribution, except for higher temperatures, where the bypass variant tends to fail due to blockage. Thiamine hydrochloride, a substance forming long and fragile needles in aqueous solutions, is solidified with an anti-solvent crystallization with ethanol. The novel inline probe could identify a new field of application for image-based crystal size distribution measurements, with respect to difficult particle shapes (needles) and elevated temperatures, which cannot be evaluated with common techniques. View Full-Text
Keywords: optical measurement techniques; crystal size measurement; inline probe; crystal needles optical measurement techniques; crystal size measurement; inline probe; crystal needles
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MDPI and ACS Style

Wirz, D.; Hofmann, M.; Lorenz, H.; Bart, H.-J.; Seidel-Morgenstern, A.; Temmel, E. A Novel Shadowgraphic Inline Measurement Technique for Image-Based Crystal Size Distribution Analysis. Crystals 2020, 10, 740. https://doi.org/10.3390/cryst10090740

AMA Style

Wirz D, Hofmann M, Lorenz H, Bart H-J, Seidel-Morgenstern A, Temmel E. A Novel Shadowgraphic Inline Measurement Technique for Image-Based Crystal Size Distribution Analysis. Crystals. 2020; 10(9):740. https://doi.org/10.3390/cryst10090740

Chicago/Turabian Style

Wirz, Dominic, Marc Hofmann, Heike Lorenz, Hans-Jörg Bart, Andreas Seidel-Morgenstern, and Erik Temmel. 2020. "A Novel Shadowgraphic Inline Measurement Technique for Image-Based Crystal Size Distribution Analysis" Crystals 10, no. 9: 740. https://doi.org/10.3390/cryst10090740

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