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Open AccessCommunication

Enzymatic Synthesis of Thioesters from Thiols and Vinyl Esters in a Continuous-Flow Microreactor

1
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
2
Department of Environmental Science and Technology, Zhejiang A&F University, Hangzhou 311300, China
*
Authors to whom correspondence should be addressed.
Catalysts 2018, 8(6), 249; https://doi.org/10.3390/catal8060249
Received: 16 May 2018 / Revised: 6 June 2018 / Accepted: 14 June 2018 / Published: 16 June 2018
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Abstract

The preparation of thioesters through the lipase-catalysed transesterification reaction of thiols with vinyl carboxyl esters is described. The reactions were carried out by Lipase TL IM from Thermomyces lanuginosus as a catalyst and performed under a continuous flow microreactor. We first found that lipase TL IM can be used in the reaction of thioester synthesis with high efficiency. Various reaction parameters were investigated including substrate molar ratio, reaction time, and temperature. Maximum conversion (96%) was obtained under the optimal condition of a substrate molar ratio of 1:2 (4-methylbenzyl mercaptan:vinyl esters) at 50 °C for about 30 min. Compared with other methods, the salient features of this work include mild reaction conditions (50 °C), short reaction times (30 min), high yields, and environment-friendliness. View Full-Text
Keywords: enzymatic synthesis; thioester synthesis; flow chemistry; microreactor enzymatic synthesis; thioester synthesis; flow chemistry; microreactor
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Zhou, N.; Shen, L.; Dong, Z.; Shen, J.; Du, L.; Luo, X. Enzymatic Synthesis of Thioesters from Thiols and Vinyl Esters in a Continuous-Flow Microreactor. Catalysts 2018, 8, 249.

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