Next Article in Journal
Diastereoselective Synthesis of 7,8-Carvone Epoxides
Previous Article in Journal
Mode Transition of Filaments in Packed-Bed Dielectric Barrier Discharges
Open AccessCommunication

Enzymatic Synthesis of Thioesters from Thiols and Vinyl Esters in a Continuous-Flow Microreactor

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
Department of Environmental Science and Technology, Zhejiang A&F University, Hangzhou 311300, China
Authors to whom correspondence should be addressed.
Catalysts 2018, 8(6), 249;
Received: 16 May 2018 / Revised: 6 June 2018 / Accepted: 14 June 2018 / Published: 16 June 2018
PDF [8154 KB, uploaded 16 June 2018]


The preparation of thioesters through the lipase-catalysed transesterification reaction of thiols with vinyl carboxyl esters is described. The reactions were carried out by Lipase TL IM from Thermomyces lanuginosus as a catalyst and performed under a continuous flow microreactor. We first found that lipase TL IM can be used in the reaction of thioester synthesis with high efficiency. Various reaction parameters were investigated including substrate molar ratio, reaction time, and temperature. Maximum conversion (96%) was obtained under the optimal condition of a substrate molar ratio of 1:2 (4-methylbenzyl mercaptan:vinyl esters) at 50 °C for about 30 min. Compared with other methods, the salient features of this work include mild reaction conditions (50 °C), short reaction times (30 min), high yields, and environment-friendliness. View Full-Text
Keywords: enzymatic synthesis; thioester synthesis; flow chemistry; microreactor enzymatic synthesis; thioester synthesis; flow chemistry; microreactor

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Zhou, N.; Shen, L.; Dong, Z.; Shen, J.; Du, L.; Luo, X. Enzymatic Synthesis of Thioesters from Thiols and Vinyl Esters in a Continuous-Flow Microreactor. Catalysts 2018, 8, 249.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Catalysts EISSN 2073-4344 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top