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Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow

Centre de Recherche Royallieu, Université de Technologie de Compiègne (UTC), Sorbonne Universités, CS 60319, F-60203 Compiègne CEDEX, France
Ecole Supérieure de Chimie Organique et Minérale (ESCOM), 1 rue du Réseau Jean-Marie Buckmaster, F-60200 Compiègne, France
Institute of Advanced Sciences, 86-410 Faunce Corner Mall Road, Dartmouth, MA 02747, USA
Author to whom correspondence should be addressed.
Academic Editor: Ioannis D. Kostas
Catalysts 2017, 7(5), 146;
Received: 15 March 2017 / Revised: 18 April 2017 / Accepted: 25 April 2017 / Published: 9 May 2017
(This article belongs to the Special Issue Suzuki–Miyaura Cross-Coupling Reaction and Potential Applications)


Carbon–carbon cross-coupling reactions are among the most important processes in organic chemistry and Suzuki–Miyaura reactions are the most widely used protocols. For a decade, green chemistry and particularly catalysis and continuous flow, have shown immense potential in achieving the goals of “greener synthesis”. To date, it seems difficult to conceive the chemistry of the 21st century without the industrialization of continuous flow process in the area of pharmaceuticals, drugs, agrochemicals, polymers, etc. A large variety of palladium Suzuki–Miyaura cross-coupling reactions have been developed using a continuous flow sequence for preparing the desired biaryl derivatives. Our objective is to focus this review on the continuous flow Suzuki–Miyaura cross-coupling using homogeneous and heterogeneous catalysts. View Full-Text
Keywords: palladium; continuous flow; Suzuki–Miyaura; cross-coupling palladium; continuous flow; Suzuki–Miyaura; cross-coupling

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Len, C.; Bruniaux, S.; Delbecq, F.; Parmar, V.S. Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow. Catalysts 2017, 7, 146.

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