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Open AccessArticle

Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process

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Institute of Chemical Reaction Technology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany
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Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
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Medicinal Chemistry Department, National Research Centre, El Buhouth St., Dokki, Cairo 12622, Egypt
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Department of Chemistry, Faculty of Science, University of Jeddah, P.O. Box 80329, Jeddah 21589, Saudi Arabia
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Green Chemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt
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Surface Chemistry and Catalysis Lab, Physical Chemistry Department, National Research Centre, El Buhouth St., Dokki, Cairo 12622, Egypt
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Authors to whom correspondence should be addressed.
Academic Editor: Giancarlo Cravotto
Catalysts 2017, 7(3), 84; https://doi.org/10.3390/catal7030084
Received: 3 February 2017 / Revised: 27 February 2017 / Accepted: 6 March 2017 / Published: 13 March 2017
(This article belongs to the Special Issue Enabling Technologies toward Green Catalysis)
A sustainable, green one-pot process for the synthesis of dihydropyrimidinones (DHPMs) derivatives by a three-component reaction of β-ketoester derivatives, aldehyde and urea or thiourea over the alkali-treated H-ZSM-5 zeolite under ball-milling was developed. Isolation of the product with ethyl acetate shadowed by vanishing of solvent was applied. The hierachical zeolite catalyst (MFI27_6) showed high yield (86%–96%) of DHPMs in a very short time (10–30 min). The recyclability of the catalyst for the subsequent reactions was examined in four subsequent runs. The catalyst was shown to be robust without a detectable reduction in catalytic activity, and high yields of products showed the efficient protocol of the Biginelli reactions. View Full-Text
Keywords: hierarchical; MFI27; Biginelli; dihydropyrimidinones; ball mill hierarchical; MFI27; Biginelli; dihydropyrimidinones; ball mill
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MDPI and ACS Style

Shahid, A.; Ahmed, N.S.; Saleh, T.S.; Al-Thabaiti, S.A.; Basahel, S.N.; Schwieger, W.; Mokhtar, M. Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts 2017, 7, 84.

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