A Novel Oxidation of Salicyl Alcohols Catalyzed by Lipase
by
Ziyuan Zhao 1, Liu Zhang 1, Fengxi Li 1, Xuyong Tang 1, Yuwen Ma 1, Chunyu Wang 2, Zhi Wang 1, Rui Zhao 3,* and Lei Wang 1,*
Ziyuan Zhao 1, Liu Zhang 1, Fengxi Li 1, Xuyong Tang 1, Yuwen Ma 1, Chunyu Wang 2, Zhi Wang 1, Rui Zhao 3,* and Lei Wang 1,*
1
Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun 130000, China
2
State Key Laborarory of Supramolecular Structure and Materials, Jilin University, 2699 Qianjin Street, Changchun 130000, China
3
China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130000, China
*
Authors to whom correspondence should be addressed.
Catalysts 2017, 7(12), 354; https://doi.org/10.3390/catal7120354
Received: 26 October 2017 / Revised: 18 November 2017 / Accepted: 20 November 2017 / Published: 23 November 2017
A novel and efficient oxidation of salicyl alcohols to the corresponding salicylaldehydes catalyzed by lipase is reported for the first time. Under the optimal reaction conditions, the method exhibited high yields (81–95%) and selectivities for salicylaldehydes. Moreover, this study expands the application of enzyme catalytic promiscuity in organic synthesis.
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Keywords:
promiscuity; lipase; TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy); oxidation; salicyl alcohol
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MDPI and ACS Style
Zhao, Z.; Zhang, L.; Li, F.; Tang, X.; Ma, Y.; Wang, C.; Wang, Z.; Zhao, R.; Wang, L. A Novel Oxidation of Salicyl Alcohols Catalyzed by Lipase. Catalysts 2017, 7, 354.
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