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Review

State of the Art on the Microbial Production of Industrially Relevant Organic Acids

1
Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
2
Institute of Molecular Bioimaging and Physiology (IBFM), C.N.R. (National Research Council), Via F.lli Cervi 93, 20090 Segrate, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Gloria Fernandez-Lorente
Catalysts 2022, 12(2), 234; https://doi.org/10.3390/catal12020234
Received: 31 December 2021 / Revised: 9 February 2022 / Accepted: 15 February 2022 / Published: 19 February 2022
(This article belongs to the Section Biocatalysis)
The industrial relevance of organic acids is high; because of their chemical properties, they can be used as building blocks as well as single-molecule agents with a huge annual market. Organic acid chemical platforms can derive from fossil sources by petrochemical refining processes, but most of them also represent natural metabolites produced by many cells. They are the products, by-products or co-products of many primary metabolic processes of microbial cells. Thanks to the potential of microbial cell factories and to the development of industrial biotechnology, from the last decades of the previous century, the microbial-based production of these molecules has started to approach the market. This was possible because of a joint effort of microbial biotechnologists and biochemical and process engineers that boosted natural production up to the titer, yield and productivity needed to be industrially competitive. More recently, the possibility to utilize renewable residual biomasses as feedstock not only for biofuels, but also for organic acids production is further augmenting the sustainability of their production, in a logic of circular bioeconomy. In this review, we briefly present the latest updates regarding the production of some industrially relevant organic acids (citric fumaric, itaconic, lactic and succinic acid), discussing the challenges and possible future developments of successful production. View Full-Text
Keywords: industrial biotechnology; microbial cell factories; organic acids; bioeconomy industrial biotechnology; microbial cell factories; organic acids; bioeconomy
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MDPI and ACS Style

Di Lorenzo, R.D.; Serra, I.; Porro, D.; Branduardi, P. State of the Art on the Microbial Production of Industrially Relevant Organic Acids. Catalysts 2022, 12, 234. https://doi.org/10.3390/catal12020234

AMA Style

Di Lorenzo RD, Serra I, Porro D, Branduardi P. State of the Art on the Microbial Production of Industrially Relevant Organic Acids. Catalysts. 2022; 12(2):234. https://doi.org/10.3390/catal12020234

Chicago/Turabian Style

Di Lorenzo, Raffaella D., Immacolata Serra, Danilo Porro, and Paola Branduardi. 2022. "State of the Art on the Microbial Production of Industrially Relevant Organic Acids" Catalysts 12, no. 2: 234. https://doi.org/10.3390/catal12020234

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