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Direct Electrochemical Enzyme Electron Transfer on Electrodes Modified by Self-Assembled Molecular Monolayers

Department of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
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Author to whom correspondence should be addressed.
Catalysts 2020, 10(12), 1458; https://doi.org/10.3390/catal10121458
Received: 8 November 2020 / Revised: 29 November 2020 / Accepted: 10 December 2020 / Published: 14 December 2020
(This article belongs to the Special Issue Enzymatic Bioelectrocatalysis)
Self-assembled molecular monolayers (SAMs) have long been recognized as crucial “bridges” between redox enzymes and solid electrode surfaces, on which the enzymes undergo direct electron transfer (DET)—for example, in enzymatic biofuel cells (EBFCs) and biosensors. SAMs possess a wide range of terminal groups that enable productive enzyme adsorption and fine-tuning in favorable orientations on the electrode. The tunneling distance and SAM chain length, and the contacting terminal SAM groups, are the most significant controlling factors in DET-type bioelectrocatalysis. In particular, SAM-modified nanostructured electrode materials have recently been extensively explored to improve the catalytic activity and stability of redox proteins immobilized on electrochemical surfaces. In this report, we present an overview of recent investigations of electrochemical enzyme DET processes on SAMs with a focus on single-crystal and nanoporous gold electrodes. Specifically, we consider the preparation and characterization methods of SAMs, as well as SAM applications in promoting interfacial electrochemical electron transfer of redox proteins and enzymes. The strategic selection of SAMs to accord with the properties of the core redox protein/enzymes is also highlighted. View Full-Text
Keywords: self-assembled molecular monolayers; electron transfer; direct electron transfer; bioelectrocatalysis; oxidoreductase; gold electrode; metallic nanostructures self-assembled molecular monolayers; electron transfer; direct electron transfer; bioelectrocatalysis; oxidoreductase; gold electrode; metallic nanostructures
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MDPI and ACS Style

Yan, X.; Tang, J.; Tanner, D.; Ulstrup, J.; Xiao, X. Direct Electrochemical Enzyme Electron Transfer on Electrodes Modified by Self-Assembled Molecular Monolayers. Catalysts 2020, 10, 1458. https://doi.org/10.3390/catal10121458

AMA Style

Yan X, Tang J, Tanner D, Ulstrup J, Xiao X. Direct Electrochemical Enzyme Electron Transfer on Electrodes Modified by Self-Assembled Molecular Monolayers. Catalysts. 2020; 10(12):1458. https://doi.org/10.3390/catal10121458

Chicago/Turabian Style

Yan, Xiaomei, Jing Tang, David Tanner, Jens Ulstrup, and Xinxin Xiao. 2020. "Direct Electrochemical Enzyme Electron Transfer on Electrodes Modified by Self-Assembled Molecular Monolayers" Catalysts 10, no. 12: 1458. https://doi.org/10.3390/catal10121458

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