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Cancers 2017, 9(7), 94;

Targeting Platelets for the Treatment of Cancer

Faculty of Health Sciences, Curtin University, Perth 6100, Australia
Curtin Health Innovation Research Institute (CHIRI), Curtin University, Perth 6100, Australia
School of Biomedical Sciences, Curtin University, Perth 6100, Australia
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 30 June 2017 / Revised: 18 July 2017 / Accepted: 19 July 2017 / Published: 22 July 2017
Full-Text   |   PDF [2000 KB, uploaded 25 July 2017]   |  


The majority of cancer-associated mortality results from the ability of tumour cells to metastasise leading to multifunctional organ failure and death. Disseminated tumour cells in the blood circulation are faced with major challenges such as rheological shear stresses and cell-mediated cytotoxicity mediated by natural killer cells. Nevertheless, circulating tumour cells with metastatic ability appear equipped to exploit host cells to aid their survival. Despite the long interest in targeting tumour-associated host cells such as platelets for cancer treatment, the clinical benefit of this strategy is still under question. In this review, we provide a summary of the latest mechanistic and clinical evidence to evaluate the validity of targeting platelets in cancer. View Full-Text
Keywords: cancer; cancer therapy; platelet; antiplatelet cancer; cancer therapy; platelet; antiplatelet

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Elaskalani, O.; Berndt, M.C.; Falasca, M.; Metharom, P. Targeting Platelets for the Treatment of Cancer. Cancers 2017, 9, 94.

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