Next Article in Journal
A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland
Next Article in Special Issue
Photodynamic Synergistic Effect of Pheophorbide a and Doxorubicin in Combined Treatment against Tumoral Cells
Previous Article in Journal
Care at the Very End-of-Life: Dying Cancer Patients and Their Chosen Family’s Needs
Previous Article in Special Issue
A Comparison of Singlet Oxygen Explicit Dosimetry (SOED) and Singlet Oxygen Luminescence Dosimetry (SOLD) for Photofrin-Mediated Photodynamic Therapy

Interstitial Photodynamic Therapy—A Focused Review

Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA
Simphotek, Inc., 211 Warren St, Newark, NJ 07103, USA
Author to whom correspondence should be addressed.
Academic Editor: Michael R. Hamblin
Cancers 2017, 9(2), 12;
Received: 1 December 2016 / Revised: 13 January 2017 / Accepted: 20 January 2017 / Published: 24 January 2017
(This article belongs to the Special Issue Photodynamic Cancer Therapy)
Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response. View Full-Text
Keywords: interstitial photodynamic therapy; prostate; head and neck; pancreatic; brain; treatment planning interstitial photodynamic therapy; prostate; head and neck; pancreatic; brain; treatment planning
Show Figures

Figure 1

MDPI and ACS Style

Shafirstein, G.; Bellnier, D.; Oakley, E.; Hamilton, S.; Potasek, M.; Beeson, K.; Parilov, E. Interstitial Photodynamic Therapy—A Focused Review. Cancers 2017, 9, 12.

AMA Style

Shafirstein G, Bellnier D, Oakley E, Hamilton S, Potasek M, Beeson K, Parilov E. Interstitial Photodynamic Therapy—A Focused Review. Cancers. 2017; 9(2):12.

Chicago/Turabian Style

Shafirstein, Gal, David Bellnier, Emily Oakley, Sasheen Hamilton, Mary Potasek, Karl Beeson, and Evgueni Parilov. 2017. "Interstitial Photodynamic Therapy—A Focused Review" Cancers 9, no. 2: 12.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop