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Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women

1
Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
2
Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
3
Harbor UCLA Medical Center, Torrance, CA 90509, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Cancers 2017, 9(10), 144; https://doi.org/10.3390/cancers9100144
Received: 17 August 2017 / Revised: 22 September 2017 / Accepted: 19 October 2017 / Published: 24 October 2017
Background: This study investigated the association of vitamin D3 levels with breast cancer risk and progression in African-Americans and Hispanics. Methods: A total of 237 African-American (Cases = 119, Control = 118) and 423 Hispanic women (Cases = 124, Control = 299) were recruited in the study. Blood samples were collected at the time of breast cancer screening and prior to cancer treatment for 4 weeks on average for the cases. The serum 25-hydroxyvitamin D (25(OH)D3) was measured at a Quest-Diagnostics facility. Results: The results showed that 69.2% of African-Americans and 37.8% of Hispanics had 25(OH)D3 levels below 20 ng/mL. The 25(OH)D3 level below 20 ng/mL was significantly associated with breast cancer in both African-Americans (OR = 2.5, 95% CI = 1.3–4.8) and Hispanics (OR = 1.9, 95% CI = 1.1–3.0). However, the predicted probabilities of breast cancer in African-Americans were significantly higher than in Hispanics (p < 0.001). The 25(OH)D3 below 20 ng/mL was significantly associated with triple negative breast cancer (TNBC) in African-Americans (OR = 5.4, p = 0.02, 95% CI = 1.4–15), but not in Hispanics in our cohort of participants. Levels of 25(OH)D3 below 26 ng/mL predicts a decrease in disease-free survival, but it was not an independent predictor. Conclusions: Our data shows an association between 25(OH)D3 levels and the risk of breast cancer. Further studies on the relationship between 25(OH)D3 level and breast cancer risk are warranted. View Full-Text
Keywords: vitamin D; breast cancer; African-American women; Hispanic women; disparity; metastases vitamin D; breast cancer; African-American women; Hispanic women; disparity; metastases
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Wu, Y.; Sarkissyan, M.; Clayton, S.; Chlebowski, R.; Vadgama, J.V. Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women. Cancers 2017, 9, 144.

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