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Cancers 2015, 7(3), 1388-1405;

MicroRNAs in Cancer: A Historical Perspective on the Path from Discovery to Therapy

Department of Biological Sciences, Bindley Bioscience Center, Purdue University, 1203 West State Street, West Lafayette, IN 47907, USA
Purdue University Interdisciplinary Life Science Program (PULSe), West Lafayette, IN 47907, USA
Author to whom correspondence should be addressed.
Academic Editor: Charles H. Lawrie
Received: 24 June 2015 / Revised: 17 July 2015 / Accepted: 20 July 2015 / Published: 27 July 2015
(This article belongs to the Special Issue Non-Coding RNAs in Cancers)
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Recent progress in microRNA (miRNA) therapeutics has been strongly dependent on multiple seminal discoveries in the area of miRNA biology during the past two decades. In this review, we focus on the historical discoveries that collectively led to transitioning miRNAs into the clinic. We highlight the pivotal studies that identified the first miRNAs in Caenorhabditis elegans to the more recent reports that have fueled the quest to understand the use of miRNAs as markers for cancer diagnosis and prognosis. In addition, we provide insights as to how unraveling basic miRNA biology has provided a solid foundation for advancing miRNAs, such as miR-34a, therapeutically. We conclude with a brief examination of the current challenges that still need to be addressed to accelerate the path of miRNAs to the clinic: including delivery vehicles, miRNA- and delivery-associated toxicity, dosage, and off target effects. View Full-Text
Keywords: microRNA; history; cancer; therapeutics microRNA; history; cancer; therapeutics

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Orellana, E.A.; Kasinski, A.L. MicroRNAs in Cancer: A Historical Perspective on the Path from Discovery to Therapy. Cancers 2015, 7, 1388-1405.

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