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Cancers 2013, 5(4), 1306-1331; doi:10.3390/cancers5041306

MicroRNA in Human Glioma

1,2,* , 1,3
Received: 22 September 2013 / Revised: 8 October 2013 / Accepted: 10 October 2013 / Published: 23 October 2013
(This article belongs to the Special Issue Glioblastoma)
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Glioma represents a serious health problem worldwide. Despite advances in surgery, radiotherapy, chemotherapy, and targeting therapy, the disease remains one of the most lethal malignancies in humans, and new approaches to improvement of the efficacy of anti-glioma treatments are urgently needed. Thus, new therapeutic targets and tools should be developed based on a better understanding of the molecular pathogenesis of glioma. In this context, microRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in the development of the malignant phenotype of glioma cells, including cell survival, proliferation, differentiation, tumor angiogenesis, and stem cell generation. This review will discuss the biological functions of miRNAs in human glioma and their implications in improving clinical diagnosis, prediction of prognosis, and anti-glioma therapy.
Keywords: glioma; microRNA; biological function; gap filler; amplifier; crosstalk; biomarker glioma; microRNA; biological function; gap filler; amplifier; crosstalk; biomarker
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, M.; Li, J.; Liu, L.; Li, W.; Yang, Y.; Yuan, J. MicroRNA in Human Glioma. Cancers 2013, 5, 1306-1331.

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