Cancers 2013, 5(4), 1306-1331; doi:10.3390/cancers5041306

MicroRNA in Human Glioma

1,2,* email, 1,3email, 1,2email, 1,2email, 1,4email and 1,5email
1 Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080, China 2 Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China 3 Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China 4 Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China 5 Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China
* Author to whom correspondence should be addressed.
Received: 22 September 2013; in revised form: 8 October 2013 / Accepted: 10 October 2013 / Published: 23 October 2013
(This article belongs to the Special Issue Glioblastoma)
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Abstract: Glioma represents a serious health problem worldwide. Despite advances in surgery, radiotherapy, chemotherapy, and targeting therapy, the disease remains one of the most lethal malignancies in humans, and new approaches to improvement of the efficacy of anti-glioma treatments are urgently needed. Thus, new therapeutic targets and tools should be developed based on a better understanding of the molecular pathogenesis of glioma. In this context, microRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in the development of the malignant phenotype of glioma cells, including cell survival, proliferation, differentiation, tumor angiogenesis, and stem cell generation. This review will discuss the biological functions of miRNAs in human glioma and their implications in improving clinical diagnosis, prediction of prognosis, and anti-glioma therapy.
Keywords: glioma; microRNA; biological function; gap filler; amplifier; crosstalk; biomarker

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MDPI and ACS Style

Li, M.; Li, J.; Liu, L.; Li, W.; Yang, Y.; Yuan, J. MicroRNA in Human Glioma. Cancers 2013, 5, 1306-1331.

AMA Style

Li M, Li J, Liu L, Li W, Yang Y, Yuan J. MicroRNA in Human Glioma. Cancers. 2013; 5(4):1306-1331.

Chicago/Turabian Style

Li, Mengfeng; Li, Jun; Liu, Lei; Li, Wei; Yang, Yi; Yuan, Jie. 2013. "MicroRNA in Human Glioma." Cancers 5, no. 4: 1306-1331.

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