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Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results

1
Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
2
Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
3
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
4
Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Cancers 2013, 5(2), 529-549; https://doi.org/10.3390/cancers5020529
Received: 21 March 2013 / Revised: 16 April 2013 / Accepted: 2 May 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Soft Tissue and Bone Sarcoma)
Liposarcoma is one of the most common adult soft tissue sarcomas and consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of several novel systemic therapies. Data from phase I and early phase II clinical trials have been reported. Despite challenges with conducting clinical trials in liposarcoma, preliminary results for several of these novel, biology-driven therapies are encouraging. View Full-Text
Keywords: liposarcoma; chemotherapy; molecular-based therapy; clinical trials liposarcoma; chemotherapy; molecular-based therapy; clinical trials
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Tseng, W.W.; Somaiah, N.; Lazar, A.J.; Lev, D.C.; Pollock, R.E. Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results. Cancers 2013, 5, 529-549.

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