Next Article in Journal
Immune Response to Sipuleucel-T in Prostate Cancer
Next Article in Special Issue
P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells
Previous Article in Journal
External Beam Radiotherapy of Recurrent Glioma: Radiation Tolerance of the Human Brain
Previous Article in Special Issue
Remodeling of Tumor Stroma and Response to Therapy
Open AccessReview

The Dynamics of Developmental and Tumor Angiogenesis—A Comparison

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden
Author to whom correspondence should be addressed.
Cancers 2012, 4(2), 400-419;
Received: 1 March 2012 / Revised: 3 April 2012 / Accepted: 4 April 2012 / Published: 11 April 2012
(This article belongs to the Special Issue Tumor Stroma)
The blood vasculature in cancers has been the subject of intense interest during the past four decades. Since the original ideas of targeting angiogenesis to treat cancer were proposed in the 1970s, it has become evident that more knowledge about the role of vessels in tumor biology is needed to fully take advantage of such strategies. The vasculature serves the surrounding tissue in a multitude of ways that all must be taken into consideration in therapeutic manipulation. Aspects of delivery of conventional cytostatic drugs, induction of hypoxia affecting treatment by radiotherapy, changes in tumor cell metabolism, vascular leak and trafficking of leukocytes are affected by interventions on vascular function. Many tumors constitute a highly interchangeable milieu undergoing proliferation, apoptosis, and necrosis with abundance of growth factors, enzymes and metabolites. These aspects are reflected by the abnormal tortuous, leaky vascular bed with detached mural cells (pericytes). The vascular bed of tumors is known to be unstable and undergoing remodeling, but it is not until recently that this has been dynamically demonstrated at high resolution, facilitated by technical advances in intravital microscopy. In this review we discuss developmental genetic loss-of-function experiments in the light of tumor angiogenesis. We find this a valid comparison since many studies phenocopy the vasculature in development and tumors. View Full-Text
Keywords: angiogenesis; VEGF; sprouting; tip cell; vascular dynamics; tumor; cancer; blood vessels, remodeling, tumor stroma angiogenesis; VEGF; sprouting; tip cell; vascular dynamics; tumor; cancer; blood vessels, remodeling, tumor stroma
MDPI and ACS Style

Jin, Y.; Jakobsson, L. The Dynamics of Developmental and Tumor Angiogenesis—A Comparison. Cancers 2012, 4, 400-419.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop