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X Inactivation and Progenitor Cancer Cells

Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Cancers 2011, 3(2), 2169-2175;
Received: 11 February 2011 / Revised: 16 March 2011 / Accepted: 12 April 2011 / Published: 26 April 2011
(This article belongs to the Special Issue Cancer Stem Cells)
PDF [133 KB, uploaded 27 April 2011]


In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing. View Full-Text
Keywords: X inactivation; Xist RNA; chromatin; cancer; epigenetics X inactivation; Xist RNA; chromatin; cancer; epigenetics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Agrelo, R. X Inactivation and Progenitor Cancer Cells. Cancers 2011, 3, 2169-2175.

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