Circulating Tumor Cells, Enumeration and Beyond
Abstract
:1. Introduction
2. Cytometric Methods of CTC Detection
3. Size Exclusion Methods of CTC Detection
4. Heterogeneity in CTCs, Unexplored Territory
4.1. Cytopathology of CTCs
4.2. Pharmacological Biomarkers Measured in CTCs
4.3. Characterization of Cytogenetic Abnormalities of CTCs
5. Omics Approaches for Molecular Profiling of CTCs
6. Purification of CTCs
7. Horizon Scanning
- (i)
- will baseline CTC signatures reveal predictive biomarkers for targeted therapy?
- (ii)
- will signatures from CTCs from chemo-sensitive patients versus those from chemo-resistant patients inform on mechanisms of drug resistance?
- (iii)
- will longitundinal CTC signatures at diagnosis versus disease relapse after initial responses to therapy inform on acquired drug resistance and/or identify a ‘stem like’ tumor cell?
- (iv)
- will comparative signatures from matched primary and secondary tumors and CTCs shed additional light on molecular events important for metastasis?
- (v)
- will CTC signatures aid discovery and development of anti-metastatic drugs?
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Hou, J.-M.; Krebs, M.; Ward, T.; Morris, K.; Sloane, R.; Blackhall, F.; Dive, C. Circulating Tumor Cells, Enumeration and Beyond. Cancers 2010, 2, 1236-1250. https://doi.org/10.3390/cancers2021236
Hou J-M, Krebs M, Ward T, Morris K, Sloane R, Blackhall F, Dive C. Circulating Tumor Cells, Enumeration and Beyond. Cancers. 2010; 2(2):1236-1250. https://doi.org/10.3390/cancers2021236
Chicago/Turabian StyleHou, Jian-Mei, Matthew Krebs, Tim Ward, Karen Morris, Robert Sloane, Fiona Blackhall, and Caroline Dive. 2010. "Circulating Tumor Cells, Enumeration and Beyond" Cancers 2, no. 2: 1236-1250. https://doi.org/10.3390/cancers2021236