Serum Tumor Markers in Pancreatic Cancer—Recent Discoveries
Abstract
:1. Introduction
2. Serum Tumor Markers for Pancreatic Cancer
2.1. Tumor Associated Antigens
2.1.1. Carbohydrate Antigens
2.1.1.1. CA19-9
Type of marker | Author | Sensitivity | Specificity | Patients tested (n) |
---|---|---|---|---|
CA19-9 | Steinberg [13] | 81 | 90 | meta |
Goonetilleke [14] | 79 | 82 | meta | |
CA50 | Kobayashi [15] | 84 | 85 | 200 |
Jiang [19] | 78 | 70 | 129 | |
CA242 | Banfi [20] | 57 | 93 | 41 |
Jiang [19] | 82 | 78 | 129 | |
Ni [21] | 60 | 76 | 68 | |
CA195 | Banfi [20] | 76 | 85 | 41 |
Andicoechea [22] | 82 | 73 | 67 | |
CA125 | Haglund [23] | 45 | 76 | 95 |
Duraker [24] | 57 | 78 | 123 | |
PAM4 | Gold [25] | 77 | 95 | 53 |
TAG-72 | Pasquali [26] | 45 | 95 | 58 |
CEA | Ni [21] | 45 | 75 | 68 |
Haglund [23] | 54 | 76 | 95 | |
Duraker [24] | 39 | 91 | 123 | |
Zhao [27] | 25 | 86 | 143 | |
POA | Nishida [28] | 81 | 96 | 21 |
Zhao [27] | 68 | 88 | 143 | |
TPA | Panucci [29] | 96 | 67 | 28 |
Benini [30] | 48 | 80 | 25 | |
Pasanen [31] | 52 | 85 | 25 | |
TPS | Banfi [20] | 98 | 22 | 41 |
Pasanen [32] | 50 | 70 | 26 | |
Du-PAN 2 | Satake [33] | 48 | 85 | 239 |
Sawabu [34] | 72 | 94 | 32 | |
Kawa [35] | 64 | - | 200 | |
SPan-1 | Kiriyama [36] | 81 | 76 | 64 |
Chung [37] | 92 | 83 | 67 | |
Kobayashi [15] | 82 | 85 | 200 | |
CAM17.1 | Parker [38] | 78 | 76 | 79 |
Gansauge [39] | 67 | 100 | 91 | |
TATI | Taccone [40] | 92 | 67 | 36 |
Pasanen [41] | 41 | 63 | 17 | |
Aroasio [42] | 63 | - | 52 | |
Elastase-1 | Zhao [27] | 62 | 67 | 143 |
GT II | Uemura [43] | 77 | 85 | 13 |
Tu M2-PK | Ventrucci [44] | 85 | 41 | 60 |
Cerwenka [45] | 79 | 90 | 38 | |
Oremek [46] | 71 | 95 | 64 | |
Mic-1 | Koopmann [47] | 90 | 94 | 50 |
Koopmann [48] | 71 | 78 | 80 |
2.1.1.2. CA50
2.1.1.3. CA242
2.1.1.4. CA195
2.1.1.5. CA125
2.1.1.6. Other Carbohydrate Antigens
2.1.2. Glycoproteins
2.1.2.1. CEA
2.1.2.2. POA
2.1.3. Cytokeratins
2.1.3.1. TPA
2.1.3.2. TPS
2.1.4. Mucins
2.1.4.1 Du-PAN 2
2.1.4.2 SPan-1
2.1.4.3. CAM17.1
2.2. Enzymatic Proteins
2.2.1. TATI
2.2.2. Tumor M2-Pyruvate Kinase
2.2.3. Elastase-1
2.2.4. Galactosyltransferase Isoenzyme II
2.3. Oncofetal Antigens
2.3.1. AFP
2.4. Other Tumor Markers
2.4.1. EPM-1
2.4.2. OPN
2.4.3. CEACAM1
2.4.4. MIC-1
3. Discussion
4. Conclusions
References
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Rückert, F.; Pilarsky, C.; Grützmann, R. Serum Tumor Markers in Pancreatic Cancer—Recent Discoveries. Cancers 2010, 2, 1107-1124. https://doi.org/10.3390/cancers2021107
Rückert F, Pilarsky C, Grützmann R. Serum Tumor Markers in Pancreatic Cancer—Recent Discoveries. Cancers. 2010; 2(2):1107-1124. https://doi.org/10.3390/cancers2021107
Chicago/Turabian StyleRückert, Felix, Christian Pilarsky, and Robert Grützmann. 2010. "Serum Tumor Markers in Pancreatic Cancer—Recent Discoveries" Cancers 2, no. 2: 1107-1124. https://doi.org/10.3390/cancers2021107