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Cancers 2010, 2(2), 1000-1012;

Wnt and Related Signaling Pathways in Melanomagenesis

University of Washington School of Medicine, Seattle, WA 98195, USA
The Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA
University of Washington Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98109, USA
Author to whom correspondence should be addressed.
Received: 27 April 2010 / Revised: 21 May 2010 / Accepted: 24 May 2010 / Published: 26 May 2010
(This article belongs to the Special Issue Current Concepts in the Diagnosis and Treatment of Cutaneous Melanoma)
Full-Text   |   PDF [285 KB, uploaded 26 May 2010]


Given the pivotal roles of morphogen pathways including Wnt, Notch, Hedgehog, and BMP pathways in the development of the neural crest lineage, it is not surprising that these signaling networks have also been implicated in the biology of malignant melanoma. Understanding the mechanisms by which these pathways can alter cell fate and other biological properties in tumor cells will be essential for determining whether the therapeutic targeting of these pathways has a potential role in melanoma treatment. This review highlights some of the recent findings with regards to how morphogen signaling may regulate melanoma cell biology. View Full-Text
Keywords: Wnts; morphogens; melanoma; signal transduction Wnts; morphogens; melanoma; signal transduction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Keller, J.J.; Moon, R.T.; Chien, A.J. Wnt and Related Signaling Pathways in Melanomagenesis. Cancers 2010, 2, 1000-1012.

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