The Incidence, Mortality, and Survival Trends of Pancreatic Cancer in Kazakhstan: Data from the National Electronic Registry of Oncological Patients (2014–2023)
Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Study Design and Population
2.2. Study Sample
2.3. Outcomes
2.4. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. Incidence, Prevalence and Mortality Trends over Time
3.3. Survival Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Total n = 11,934 | Alive n = 1807 (15.1%) | Died n = 10,127 (84.9%) | p-Value | Mortality per 1000 PY (95% CI) |
---|---|---|---|---|---|
Age, mean ± SD | 64.5 ± 11.3 | 60.2 ± 13.2 | 65.1 ± 10.8 | <0.001 | |
Age group, n (%) | <0.001 | ||||
0–29 | 62 (0.5) | 47 (75.8) | 15 (24.2) | 78 (47–130) | |
30–44 | 491 (4.2) | 139 (28.3) | 352 (71.7) | 526 (474–584) | |
45–59 | 3032 (25.9) | 475 (15.7) | 2557 (84.3) | 927 (892–964) | |
60–74 | 5872 (50.1) | 754 (12.8) | 5118 (87.2) | 1334 (1298–1371) | |
≥75 | 2267 (19.3) | 184 (8.1) | 2083 (91.9) | 1984 (1901–2071) | |
Sex, n (%) | <0.001 | ||||
Male | 5669 (49.9) | 522 (9.2) | 5147 (90.8) | 1590 (1277–1350) | |
Female | 5636 (50.1) | 673 (11.9) | 4963 (88.1) | 1313 (1548–1635) | |
Ethnicity, n (%) | 0.011 | ||||
Other | 1720 (15.2) | 192 (11.2) | 1528 (88.8) | 1308 (1244–1375) | |
Kazakh | 5952 (52.7) | 665 (11.2) | 5287 (88.8) | 1414 (1377–1453) | |
Russian | 3633 (32.1) | 338 (9.3) | 3295 (90.7) | 1560 (1508–1615) | |
Clinical stage, n (%) | <0.001 | ||||
Stage I | 429 (3.7) | 252 (58.7) | 177 (41.3) | 159 (137–184) | |
Stage II | 2214 (19.2) | 492 (22.2) | 1722 (77.8) | 693 (661–726) | |
Stage III | 4369 (37.8) | 458 (10.5) | 3911 (89.5) | 1363 (1321–1406) | |
Stage IV | 4224 (36.5) | 206 (4.9) | 4018 (95.1) | 2641 (2561–2724) | |
Unknown | 196 (1.7) | 8 (4.1) | 188 (95.9) | 4781 (4144–5515) | |
Not applicable | 128 (1.1) | 24 (18.8) | 104 (81.3) | 985 (813–1193) | |
Tumor site in the pancreas, n (%) | <0.001 | ||||
Diffuse lesion (“C25”) | 1007 (8.4) | 118 (11.7) | 889 (88.3) | 864 (809–923) | |
Head of pancreas | 7118 (59.6) | 981 (13.8) | 6137 (86.2) | 1109 (1081–1137) | |
Body of pancreas | 1600 (13.4) | 247 (15.4) | 1353 (84.6) | 1140 (1081–1202) | |
Tail of pancreas | 1070 (9.0) | 188 (17.6) | 882 (82.4) | 1005 (941–1074) | |
Pancreatic duct | 30 (0.3) | 6 (20) | 24 (80) | 535 (359–799) | |
Endocrine part | 3 (0.03) | 0 (0) | 3 (100) | 2706 (873–8389) | |
Other parts | 66 (0.5) | 12 (18.2) | 54 (81.8) | 1293 (990–1688) | |
Overlapping sites | 631 (5.3) | 61 (9.7) | 570 (90.3) | 1651 (1521–1792) | |
Unspecified part | 244 (2.1) | 34 (13.9) | 210 (86.1) | 1095 (957–1254) | |
Benign neoplasms | 165 (1.4) | 160 (97) | 5 (3) | 14 (6–33) |
Variables | Crude HR (95% CI) | p-Value | Adjusted HR (95% CI) | p-Value |
---|---|---|---|---|
Age | 1.21 [1.19–1.23] | <0.001 | 1.21 [1.19–1.24] | <0.001 |
Sex | ||||
Female | 1.00 (reference) | 1.00 (reference) | ||
Male | 1.13 [1.09–1.19] | <0.001 | 1.17 [1.06–1.20] | <0.001 |
Ethnicity | ||||
Other | 1.00 (reference) | 1.00 (reference) | ||
Kazakh | 0.99 [0.94–1.05] | 0.725 | 1.05 [0.99–1.11] | 0.130 |
Russian | 1.16 [1.10–1.24] | <0.001 | 1.13 [1.06–1.20] | <0.001 |
Clinical stage | ||||
Stage I | 1.00 (reference) | 1.00 (reference) | ||
Stage II | 2.85 [2.44–3.33] | <0.001 | 2.15 [1.83–2.51] | <0.001 |
Stage III | 4.58 [3.93–5.31] | <0.001 | 3.29 [2.82–3.83] | <0.001 |
Stage IV | 6.66 [5.72–7.75] | <0.001 | 4.80 [4.13–5.59] | <0.001 |
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Biniyazova, A.; Akhmedullin, R.; Ablayeva, A.; Beyembetova, A.; Abdukhakimova, D.; Zhumabekov, A.; Aimyshev, T.; Zhakhina, G.; Seyil, T.; Semenova, Y.; et al. The Incidence, Mortality, and Survival Trends of Pancreatic Cancer in Kazakhstan: Data from the National Electronic Registry of Oncological Patients (2014–2023). Cancers 2025, 17, 2277. https://doi.org/10.3390/cancers17142277
Biniyazova A, Akhmedullin R, Ablayeva A, Beyembetova A, Abdukhakimova D, Zhumabekov A, Aimyshev T, Zhakhina G, Seyil T, Semenova Y, et al. The Incidence, Mortality, and Survival Trends of Pancreatic Cancer in Kazakhstan: Data from the National Electronic Registry of Oncological Patients (2014–2023). Cancers. 2025; 17(14):2277. https://doi.org/10.3390/cancers17142277
Chicago/Turabian StyleBiniyazova, Aigerim, Ruslan Akhmedullin, Ayana Ablayeva, Altynay Beyembetova, Diyora Abdukhakimova, Abzal Zhumabekov, Temirgali Aimyshev, Gulnur Zhakhina, Temirlan Seyil, Yuliya Semenova, and et al. 2025. "The Incidence, Mortality, and Survival Trends of Pancreatic Cancer in Kazakhstan: Data from the National Electronic Registry of Oncological Patients (2014–2023)" Cancers 17, no. 14: 2277. https://doi.org/10.3390/cancers17142277
APA StyleBiniyazova, A., Akhmedullin, R., Ablayeva, A., Beyembetova, A., Abdukhakimova, D., Zhumabekov, A., Aimyshev, T., Zhakhina, G., Seyil, T., Semenova, Y., & Gaipov, A. (2025). The Incidence, Mortality, and Survival Trends of Pancreatic Cancer in Kazakhstan: Data from the National Electronic Registry of Oncological Patients (2014–2023). Cancers, 17(14), 2277. https://doi.org/10.3390/cancers17142277