Salvage Perioperative Interstitial High-Dose-Rate Interventional Radiotherapy (Brachytherapy) for Local Recurrences of the Chest Wall Following Mastectomy and Previous External Irradiation
Abstract
Simple Summary
Abstract
1. Introduction
2. Patients and Methods
2.1. Patients
2.2. Interventional Radiotherapy (Brachytherapy)
2.3. Follow-up
2.4. Statistical Analysis
3. Results
3.1. Patient and Tumor Characteristics
3.2. HDR-IRT Treatment Characteristics
3.3. Treatment Outcome and Related Toxicities
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | Value | Number (%) |
---|---|---|
Initial T stage | T0 T1 T2 T3 T4 Unknown | 1 (1.8%) 11 (19.6%) 22 (39.3%) 4 (7.1%) 6 (10.7%) 12 (21.4%) |
T stage at salvage treatment | T1 T2 T3 T4 | 19 (33.9%) 32 (57.1%) 3 (5.4%) 2 (3.6%) |
Initial lymph node status | Negative Positive Unknown | 20 (35.7%) 24 (42.9%) 12 (21.4%) |
Histology type | Ductal carcinoma in situ Non-special type Lobular carcinoma Other | 1 (1.8%) 39 (69.6%) 9 (16.1%) 7 (12.5%) |
Initial histologic grade | Grade 1 Grade 2 Grade 3 Unknown | 3 (5.4%) 21 (37.5%) 17 (30.4%) 15 (26.7%) |
Histologic grade at salvage treatment | Grade 1 Grade 2 Grade 3 | 3 (5.4%) 27 (48.2%) 26 (46.4%) |
Initial surgical margin status | Negative Positive | 56 (100%) 0 (0%) |
Surgical margin status at salvage treatment | Negative Positive | 51 (47.1%) 5 (8.9) |
Estrogen/progesterone receptor status | Positive Negative Unknown | 39 (69.6%) 12 (21.4%) 5 (8.9%) |
HER2-status | Positive Negative Unknown | 22 (39.3%) 28 (50%) 6 (10.7%) |
Primary surgical operation | Mastectomy Breast conserving surgery | 43 (75.4%) 14 (24.6%) |
Previous hormonal treatment | 39 (69.6%) | |
Previous chemotherapy | 43 (76.8%) |
Parameter | Median (Range) |
---|---|
HDR-IRT dose Total dose Dose per fraction Number of fractions | 30 Gy (25–36) 2.5 Gy (2.5–4) 10 (8–12) |
Clinical target volume (CTV) | |
Volume D90% V100% V150% | 25.5 cc (16–46) 93.8% (89.5–102) 87.2% (84.3–92.8) 37.2% (33.1–42.2) |
Ipsilateral lung mean dose | 3.2% (2.7–3.8) |
Heart mean dose (in left-sided tumors) | 2.8% (2.2–3.3) |
Encountered Toxicity | Number (%) | Severity |
---|---|---|
Acute radiation dermatitis | 22 (39.3%) | Grade 1–2 |
Late skin toxicities | 19 (33.9%) | Grade 1–2 |
Fibrosis | 14 (25%) 3 (5.4%) | Grade 1–2 Grade ≥3 |
Chronic wound complications | 1 (1.8%) | Grade ≥3 |
Necrosis | 1 (1.8%) | Grade ≥3 |
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Soror, T.; Banys-Paluchowski, M.; Melchert, C.; Rades, D.; Rody, A.; Muras, K.; Xie, M.; Kovács, G. Salvage Perioperative Interstitial High-Dose-Rate Interventional Radiotherapy (Brachytherapy) for Local Recurrences of the Chest Wall Following Mastectomy and Previous External Irradiation. Cancers 2023, 15, 614. https://doi.org/10.3390/cancers15030614
Soror T, Banys-Paluchowski M, Melchert C, Rades D, Rody A, Muras K, Xie M, Kovács G. Salvage Perioperative Interstitial High-Dose-Rate Interventional Radiotherapy (Brachytherapy) for Local Recurrences of the Chest Wall Following Mastectomy and Previous External Irradiation. Cancers. 2023; 15(3):614. https://doi.org/10.3390/cancers15030614
Chicago/Turabian StyleSoror, Tamer, Maggie Banys-Paluchowski, Corinna Melchert, Dirk Rades, Achim Rody, Kerstin Muras, Meiting Xie, and György Kovács. 2023. "Salvage Perioperative Interstitial High-Dose-Rate Interventional Radiotherapy (Brachytherapy) for Local Recurrences of the Chest Wall Following Mastectomy and Previous External Irradiation" Cancers 15, no. 3: 614. https://doi.org/10.3390/cancers15030614
APA StyleSoror, T., Banys-Paluchowski, M., Melchert, C., Rades, D., Rody, A., Muras, K., Xie, M., & Kovács, G. (2023). Salvage Perioperative Interstitial High-Dose-Rate Interventional Radiotherapy (Brachytherapy) for Local Recurrences of the Chest Wall Following Mastectomy and Previous External Irradiation. Cancers, 15(3), 614. https://doi.org/10.3390/cancers15030614