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Cancers
Volume 15
Issue 23
10.3390/cancers15235517
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Article
Peer-Review Record

Monitoring Metastatic Colorectal Cancer Progression According to Reactive Oxygen Metabolite Derivative Levels

Cancers 2023, 15(23), 5517; https://doi.org/10.3390/cancers15235517
by Katsuji Sawai *, Takanori Goi, Youhei Kimura and Kenji Koneri
Reviewer 1: Anonymous
Reviewer 2:
Dipak Kumar Sahoo
Reviewer 3:
Stephen Falk
Cancers 2023, 15(23), 5517; https://doi.org/10.3390/cancers15235517
Submission received: 25 October 2023 / Revised: 19 November 2023 / Accepted: 20 November 2023 / Published: 22 November 2023
(This article belongs to the Special Issue Predictive Biomarkers for Colorectal Cancer)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The present manuscript explains the role of d-ROM levels in monitoring metastatic colorectal cancer progression.

The work was introduced well and the objective of the present study was explained well.

The methodology adopted and the study population was found to be appropriate.

The data were analysed well and the authors followed the appropriate statistical methods for analyzing the data.

The results were presented with relevant tables and figures. If the authors provide better resolution images, it will be good for the readers.

The results were discussed well with relevant literature support.

The conclusion part may be improved.

The authors need to check the references and old references may be replaced with newer one.

Reference No.8 should be checked and modified as per the journal format.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Dear authors, 

The research article “Monitoring Metastatic Colorectal Cancer Progression According to Reactive Oxygen Metabolite Derivative Levels” by Sawai et al. is interesting, and I believe that readers would benefit from it. Having said that, your original submission has some potential for improvement, and some of the issues need to be addressed, for which I recommend minor revision. I've included a few of them below: 

A brief description of the role of oxidative stress and cancer/colorectal cancer development could be included in the introduction section: 


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996905/ 

https://www.frontiersin.org/articles/10.3389/fendo.2023.1217165/full 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135609/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698080/ 

https://www.mdpi.com/2072-6694/14/14/3525 

https://ar.iiarjournals.org/content/37/9/4759 

https://www.hindawi.com/journals/bmri/2013/725710/ 

 

Please provide better images (with higher resolution) for Figures 1 and 2.  

 

I was wondering if the authors obtained any informed consent for this trial (please see the details https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980471/) 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

This is a novel and interesting approach 

My only concern is the machine itself being termed carpe diem 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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