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Hepatocellular Carcinoma: The Role of Immunotherapy and Transplantation in the Era of Transplant Oncology
 
 
Review
Peer-Review Record

Transplant Oncology: An Emerging Discipline of Cancer Treatment

Cancers 2023, 15(22), 5337; https://doi.org/10.3390/cancers15225337
by Maen Abdelrahim 1,2,3,*, Abdullah Esmail 1, Ala Abudayyeh 4, Naoka Murakami 5, David Victor 3,6, Sudha Kodali 3,6, Yee Lee Cheah 6, Caroline J. Simon 6, Mazen Noureddin 3,6, Ashton Connor 3,6, Ashish Saharia 3,6, Linda W. Moore 3,6, Kirk Heyne 1,3, Ahmed O. Kaseb 7, A. Osama Gaber 3,6 and Rafik Mark Ghobrial 3,6
Reviewer 1:
Cancers 2023, 15(22), 5337; https://doi.org/10.3390/cancers15225337
Submission received: 20 October 2023 / Accepted: 30 October 2023 / Published: 9 November 2023
(This article belongs to the Special Issue Immunotherapy and Transplantation in the Era of Transplant Oncology)

Round 1

Reviewer 1 Report (Previous Reviewer 2)

Comments and Suggestions for Authors

no additional comments

Reviewer 2 Report (Previous Reviewer 3)

Comments and Suggestions for Authors

The authors addressed the questions. On my site, the manuscript is now suitable for publication. 

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.


Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

All questions were well responded. Thank you. 

Reviewer 2 Report

Comments and Suggestions for Authors

none

Reviewer 3 Report

Comments and Suggestions for Authors

The Authors of this narrative review illustrated a new topic: transplant oncology. However, other reviews have already been published, according to this fact to be published, this review will summarise all the evidence reported in the literature.

 

Nevertheless, several important steps are described. However, at least two major issues need to be introduced and detailed.

1. The authors reported the results achieved by liver transplantation and compared them with non-transplant alternatives for treating hepatocellular carcinoma. This approach should be implemented for other neoplastic diseases to underline the advantage (if any) of the transplant approach.

2. The Authors reported the results of various experiences in the 4 main paragraphs (Hepatocellular Carcinoma, non-hepatocellular carcinomas (cholangiocarcinoma, hepatoblastoma, liver metastasis from colorectal cancer, liver metastases from neuroendocrine tumours). However, a table summarising the outcome (patient survival, disease-free survival) registered in the largest series will improve the quality of the review.

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