Review Reports

Round 1

Reviewer 1 Report

 It is an interesting review in which the authors intended to show the involvement of mitochondria in cancer response to treatments. However, I think that their involvement in the development and maintenance of tumors should be better and deeply described.

Moreover, references should be added. For example, on page 2, subtitle 2, item C, not even 1 reference was shown. The same problems can be found elsewhere in the text. 

Author Response

Please see the attachment.

 

Author Response File: Author Response.docx

Reviewer 2 Report

This review paper focused on the role of mitochondria on cancer resistance to therapies. This topic is of wide interest and deserves a constructive discussion.

1. Figure 1 has already been reported in prior publication (7). Authors should provide an original figure.

 

2. Discuss details in the role of mitochondria on HIF1 function.

 

3. Authors should more describe how to control mitochondrial function to improve cancer treatment by anti-mitochondrial therapy.

 

4. Correct a mistake in line 247 “employed y”.

Author Response

Please see the attachment.

 

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The authors have appropriately altered and improved the text.

Author Response

Please see attachment

 

Author Response File: Author Response.docx