Plexins as Regulators of Cancer Cell Proliferation, Migration, and Invasivity
Abstract
Simple Summary
Abstract
1. The Plexin Receptor Family
2. The Role of the Different Plexins in Tumor Progression
2.1. Type-A Plexins
2.1.1. Plexin-A1
Plexin | Modulators of Plexin-Mediated Signal Transduction | Role | Cancer Type | Refs |
---|---|---|---|---|
Plexin-A1 | Sema3A | Inhibition of proliferation | Malignant mesothelial cells | [45] |
Sema3A, NRP-1, Perlecan | Promotion of metastatic dissemination | Prostate cancer cells | [46] | |
Sema6D, VEGFR-2 | Promotion of survival and tumor growth | Malignant mesothelioma cells | [32] | |
Sema3A | Promotion of proliferation and glycolytic activity | Lung cancer cells | [48] | |
Sema3A, NRP-1 | Inhibition of proliferation | Brain tumor stem cells | [49] | |
Plexin-A2 | Enhancement of migration and invasion | Prostate cancer cells | [50] | |
Sema3C, NRP-1, MAOA, MET | Promotion of perineural invasion | Prostate cancer cells | [51] | |
Sema3A, KIAA1199 | Inhibition of apoptosis | Cervical cancer cells | [52] | |
Enabling cell proliferation and the development of tumors | Glioblastoma derived cells | [53] | ||
Plexin-A3 | Inhibition of cell invasion | Epithelial ovarian cancer cells | [54] | |
Plexin-A4 | Sema6B | Promotion of pro- proliferative signals | Glioblastoma-derived cells, lung-cancer-derived cells, malignant-melanoma-derived cells | [26] |
miR-564 | Promotion of cell proliferation and migration | Non-small cell lung carcinoma cells | [55] | |
Plexin-B1 | Sema4D | Promotion of EMT and tumor cell metastasis | Head and neck squamous cell carcinoma | [56] |
Sema4D | Promotion of cell invasion, proliferation, and migration | Osteosarcoma cells | [57] | |
Sema3C, NRP-1/2, EGFR, ErbB2, MET | Promotion of cancer growth | Castration-resistant prostate cancer cells | [31] | |
TMPRSS2-ERG | Promotion of cell migration and invasion | Prostate cancer cells | [58] | |
Promotion of cell migration and invasion | Ovarian cancer derived cells | [59] | ||
Inhibition of breast cancer cell motility | Breast cancer cells | [60] | ||
Suppression of tumorigenesis | Primary melanoma cells | [61] | ||
Inhibition of cell proliferation | Basal cell carcinoma cells | [62] | ||
Plexin-B2 | Inhibition of cell proliferation | Basal cell carcinoma cells | [62] | |
Sema4C, ErbB2 | Promotion of proliferation and development of tumor metastasis | Breast cancer derived cells | [63] | |
Sema4C, MET | Promotion of glioma and glioblastoma cell invasion | Glioma and Glioblastoma cells | [64] | |
Angiogenin | Inhibition of tumor cell proliferation and inhibition of tumor development | Glioblastoma cells, breast cancer cells, and myelogenous leukemia cells | [65] | |
Angiogenin | Enhancement of CSC stemness and resistance to chemotherapy | Prostate cancer stem cells | [66] | |
Angiogenin | Promotion of proliferation, invasion, and tumor growth | Glioblastoma cells | [67] | |
Circular RNA, Circ_0013958 | Promotion of proliferation, migration, invasion, and tumor growth | Ovarian cancer cells | [68] | |
EGFR | Promotion of proliferation, invasiveness and tumor-forming ability by constitutively active plexin-B2 | Stem cells from cancers from unknown primary tumors | [69] | |
Plexin-B3 | Sema5A | Inhibition of migration and invasion | Glioma cells | [70] |
Inhibition of migration, invasion, and tumor metastasis | Pancreatic cancer cells | [71] | ||
Promotion of cancer cell growth, cell migration, cell invasion, and tumor progression | Triple-negative breast cancer cells | [72] | ||
Plexin-C1 | Sema7A | Inhibition of tumor progression | Melanoma cells | [73] |
Inhibition of tumor progression | Glioma cells | [74] | ||
Sema7A, β1 integrin receptors | Promotion of metastasis | Melanoma and breast cancer cells | [75] | |
Promotion of migration and proliferation | Gastric cancer cells | [76] | ||
Plexin-D1 | P61-sema3E, ErbB2 | Promotion of tumor cell invasiveness and tumor cell metastasis | Melanoma cells, lung carcinoma cells, colon carcinoma cells | [34,35] |
NR4A1 | Promotion of apoptosis | Breast cancer cells | [77] | |
Sema3C, plexin-A2, NRP-1 | Promotion of cell survival | Glioma stem cells | [78] |
2.1.2. Plexin-A2
2.1.3. Plexin-A3
2.1.4. Plexin-A4
2.2. Type-B Plexins
2.2.1. Plexin-B1
2.2.2. Plexin-B2
2.2.3. Plexin-B3
2.3. Plexin-C1
2.4. Plexin-D1
3. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Toledano, S.; Neufeld, G. Plexins as Regulators of Cancer Cell Proliferation, Migration, and Invasivity. Cancers 2023, 15, 4046. https://doi.org/10.3390/cancers15164046
Toledano S, Neufeld G. Plexins as Regulators of Cancer Cell Proliferation, Migration, and Invasivity. Cancers. 2023; 15(16):4046. https://doi.org/10.3390/cancers15164046
Chicago/Turabian StyleToledano, Shira, and Gera Neufeld. 2023. "Plexins as Regulators of Cancer Cell Proliferation, Migration, and Invasivity" Cancers 15, no. 16: 4046. https://doi.org/10.3390/cancers15164046
APA StyleToledano, S., & Neufeld, G. (2023). Plexins as Regulators of Cancer Cell Proliferation, Migration, and Invasivity. Cancers, 15(16), 4046. https://doi.org/10.3390/cancers15164046