Efficacy of Tango Argentino for Cancer-Associated Fatigue and Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial
Abstract
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Participants, Study Design, and Procedure
2.2. Intervention
2.3. Outcome Measures
2.4. Statistical Analysis
3. Results
3.1. Group Comparisons
3.2. Pre-Postanalyses
3.3. Safety and Dropout
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total | Waiting | Tango | p-Value | |
---|---|---|---|---|
Number of patients, n (%) | 60 (100) | 30 (100) | 30 (100) | |
Age, years, mean (SD) | 60.5 (10.3) | 59.3 (11.0) | 61.7 (9.4) | 0.377 |
Body mass index (BMI) | ||||
Normal (18.5 ≤ BMI < 25) | 39 (65) | 21 (70) | 18 (60) | |
Overweight (25 ≤ BMI < 30) | 13 (22) | 6 (20) | 7 (23) | 0.668 |
Obese (BMI ≥ 30) | 8 (13) | 3 (10) | 5 (17) | |
Currently employed, n (%) | 23 (38) | 12 (40) | 11 (37) | 1 |
Living in partnership, n (%) | 39 (65) | 19 (63) | 20 (67) | 1 |
Years since first diagnosis: mean (SD) | 1.7 (0.7) | 1.7 (0.7) | 1.6 (0.6) | 0.614 |
UICC stages, n (%) | ||||
I | 28 (47) | 12 (40) | 16 (53) | |
II | 23 (38) | 14 (47) | 9 (30) | 0.413 |
III | 9 (15) | 4 (13) | 5 (17) | |
Hormonal status, n (%) | ||||
Premenopausal | 3 (5) | 3 (10) | 0 | |
Postmenopausal | 57 (95) | 27 (90) | 30 (100) | 0.236 |
Triple-negative status, n (%) | 6 (10) | 2 (7) | 4 (13) | 0.667 |
Oncological Interventions, n (%) | ||||
Surgery | 60 (100) | 30 (100) | 30 (100) | 1 |
Radiation | 52 (87) | 25 (83) | 27 (90) | 0.704 |
Endocrine therapy | 39 (65) | 21 (70) | 18 (60) | 0.588 |
Chemotherapy | 31 (52) | 16 (53) | 15 (50) | 1 |
Immunotherapy | 6 (10) | 3 (10) | 3 (10) | 1 |
Sportive activities, n (%) | ||||
No | 9 (15) | 5 (17) | 4 (13) | |
Occasionally | 13 (22) | 4 (13) | 9 (30) | 0.293 |
Regularly | 38 (64) | 21 (70) | 17 (57) | |
Dance experience, n (%) | ||||
No | 19 (32) | 12 (40) | 7 (23) | |
Yes, in the past | 38 (63) | 16 (53) | 22 (73) | 0.273 |
Yes, current | 3 (5) | 2 (7) | 1 (3) | |
CFS-D | ||||
Total fatigue score, mean (SD) | 32.2 (9.0) | 33.7 (7.6) | 30.6 (10.0) | 0.195 |
Physical fatigue, mean (SD) | 14.1 (4.1) | 14.9 (3.8) | 13.3 (4.2) | 0.109 |
Affective fatigue, mean (SD) | 6.9 (2.6) | 7.3 (2.2) | 6.4 (2.8) | 0.196 |
Cognitive fatigue, mean (SD) | 11.2 (3.5) | 11.4 (3.0) | 10.9 (4.0) | 0.605 |
Tango, n = 24 | Waiting, n = 28 | Tango vs. Waiting | ||||
---|---|---|---|---|---|---|
dmean (SD) | p-Value | dmean (SD) | p-Value | p-Value | d [95% CI] | |
CFS-D-total | −4.4 (5.4) | 0.001 * | −1.3 (4.4) | 0.14 | 0.03 * | −0.64 [−1.2; −0.08] |
Physical fatigue | −1.9 (2.5) | 0.002 * | −0.78 (2.6) | 0.14 | 0.13 | −0.43 [−1.0; 0.12] |
Affective fatigue | −1.0 (2.4) | 0.052 | −0.3 (1.3) | 0.32 | 0.15 | −0.42 [−1.0; 0.14] |
Cognitive fatigue | −1.5 (2.2) | 0.004 * | −0.3 (1.8) | 0.44 | 0.03 * | −0.62 [−1.2; −0.06] |
PSQI-total | −0.8 (2.5) | 0.16 | −0.8 (2.3) | 0.08 | 0.96 | 0.02 [−0.54; 0.57] |
Sleep latency | −0.3 (0.8) | 0.04 * | −0.1 (0.8) | 0.36 | 0.39 | −0.25 [−0.79; 0.30] |
Daytime sleepiness | −0.3 (0.5) | 0.03 * | −0.04 (0.6) | 0.75 | 0.16 | −0.41 [−0.97; 0.15] |
EORTC QLQ C30 | ||||||
Global health | 4.7 (16.2) | 0.18 | −1.9 (11.0) | 0.40 | 0.10 | 0.48 [−0.08; 1.03] |
Physical functioning | 3.3 (12.3) | 0.21 | −4.1 (17.8) | 0.25 | 0.09 | 0.48 [−0.08; 1.03] |
Cognitive functioning | 6.9 (17.3) | 0.07 | 0.6 (20.7) | 0.88 | 0.25 | 0.33 [−0.22; 0.88] |
Social functioning | 14.9 (27.0) | 0.01 * | 3.6 (28.3) | 0.52 | 0.16 | 0.41 [−0.14; 0.96] |
Appetite loss | 0.0 (16.7) | 1 | 8.3 (21.1) | 0.05 * | 0.13 | −0.43 [−0.98; −0.12] |
Diarrhea | −8.3 (19.8) | 0.06 | 7.1 (24.2) | 0.14 | 0.02 * | −0.69 [−1.25; −0.13] |
n = 50 | dmean | SD | p-Value |
---|---|---|---|
CFS-D-total | −3.6 | 5.8 | 0.01 * |
Physical fatigue | −1.6 | 2.8 | 0.02 * |
Affective fatigue | −1.0 | 2.3 | 0.06 * |
Cognitive fatigue | −1.1 | 2.3 | 0.002 * |
PSQI-total | −0.9 | 2.7 | 0.03 * |
Daytime sleepiness | −0.2 | 0.6 | 0.02 * |
EORTC QLQ-C30 | |||
Global health status | 5.7 | 15.6 | 0.02 * |
Physical functioning | 6.9 | 14.3 | 0.001 * |
Role functioning | 8.2 | 25.9 | 0.03 * |
Cognitive functioning | 6.3 | 19.7 | 0.03 * |
Social functioning | 9.2 | 27.6 | 0.02 * |
Fatigue | −9.8 | 17.5 | 0.0003 * |
Insomnia | −10.2 | 25.6 | 0.008 * |
Diarrhea | −8.7 | 23.9 | 0.01 * |
CFS-D, n = 50 | Total | Physical Fatigue | Cognitive Fatigue | Affective Fatigue | |
---|---|---|---|---|---|
Adjusted for | age, cancer stage, T0-value, and menopausal status | ||||
Endocrine therapy | −6.825 * | −7.725 * | −6.513 | −7.119 + | |
Reference BMI normal | |||||
BMI overweight | 2.350 | 0.900 | 3.159 | 5.239 | |
BMI obese | −7.391 | −12.882 * | −5.695 | −6.478 | |
Sports | −3.711 * | −4.732 * | −3.760 + | −3.234 | |
Dance experience | 6.781 * | 6.890 * | 6.390+ | 6.930+ | |
EORTC QLQ C30, n = 50 | QL | PF | EF | CF | FA |
Adjusted for | age, cancer stage, T0-value, and menopausal status | ||||
Endocrine therapy | −2.847 | −1.894 | 3.242 | 3.315 | −2.367 |
Reference BMI normal | |||||
BMI overweight | −0.940 | 0.624 | 5.318 | 8.703 | 5.516 |
BMI obese | 3.106 | 12.775 + | 27.671 ** | 14.755 | −6.873 |
Sports | 4.353 + | 0.941 | 3.609 | 8.44 0 ** | −5.485 * |
Dance experience | −5.071 | 1.091 | −9.575+ | −15.511 ** | 13.107 ** |
n = 56 | Completed Tango (89%) | Discontinued Tango (11%) | p-Value |
---|---|---|---|
Number of patients, n (%) | 50 (100) | 6 (100) | |
Age, years, mean (SD) | 61.3 (9.9) | 60.5 (12.2) | 0.855 |
Body mass index (BMI) | |||
Normal (18.5 ≤ BMI < 25) | 36 (72) | 2 (33) | |
Overweight (25 ≤ BMI < 30) | 10 (20) | 1 (17) | 0.012 * |
Obese (BMI ≥ 30) | 4 (8) | 3 (50) | |
Living in partnership, n (%) | 31 (62) | 5 (83) | 0.562 |
Years since first diagnosis: mean (SD) | 1.7 (0.7) | 1.4 (0.1) | 0.328 |
UICC stages, n (%) | |||
I | 23 (46) | 2 (33) | |
II | 20 (40) | 2 (33) | 0.473 |
III | 7 (14) | 2 (33) | |
Hormonal status, n (%) | |||
Premenopausal | 2 (4) | 0 | |
Postmenopausal | 48 (96) | 6 (100) | 1 |
Triple-negative status, n (%) | 4 (8) | 2 (33) | 0.231 |
Interventions, n (%) | |||
Surgery | 50 (100) | 6 (100) | 1 |
Radiation | 46 (92) | 5 (83) | 1 |
Endocrine therapy | 34 (68) | 4 (67) | 1 |
Chemotherapy | 24 (48) | 6 (100) | 0.048 * |
Immunotherapy | 6 (12) | 0 | 0.841 |
Sport activities, n (%) | |||
No | 8 (16) | 1 (17) | |
Occasionally | 11 (22) | 1 (17) | 0.955 |
Regularly | 31 (62) | 4 (67) | |
Dance experience, n (%) | |||
No | 16 (32) | 1 (17) | |
Yes, in the past | 32 (64) | 4 (67) | 0.363 |
Yes, current | 2 (4) | 1 (17) | |
QoL assessment at baseline | |||
CFS-D total, mean (SD) | 31.01 (9.26) | 37.00 (5.23) | 0.133 |
PSQI total, mean (SD) | 9.55 (3.43) | 11.50 (4.99) | 0.229 |
EORTC QLQ C30 Global health, mean (SD) | 54.42 (16.84) | 51.67 (20.00) | 0.739 |
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Schad, F.; Rieser, T.; Becker, S.; Groß, J.; Matthes, H.; Oei, S.L.; Thronicke, A. Efficacy of Tango Argentino for Cancer-Associated Fatigue and Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial. Cancers 2023, 15, 2920. https://doi.org/10.3390/cancers15112920
Schad F, Rieser T, Becker S, Groß J, Matthes H, Oei SL, Thronicke A. Efficacy of Tango Argentino for Cancer-Associated Fatigue and Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial. Cancers. 2023; 15(11):2920. https://doi.org/10.3390/cancers15112920
Chicago/Turabian StyleSchad, Friedemann, Thomas Rieser, Sarah Becker, Jessica Groß, Harald Matthes, Shiao Li Oei, and Anja Thronicke. 2023. "Efficacy of Tango Argentino for Cancer-Associated Fatigue and Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial" Cancers 15, no. 11: 2920. https://doi.org/10.3390/cancers15112920
APA StyleSchad, F., Rieser, T., Becker, S., Groß, J., Matthes, H., Oei, S. L., & Thronicke, A. (2023). Efficacy of Tango Argentino for Cancer-Associated Fatigue and Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial. Cancers, 15(11), 2920. https://doi.org/10.3390/cancers15112920