The Importance of Detecting, Quantifying, and Characterizing Exosomes as a New Diagnostic/Prognostic Approach for Tumor Patients
Abstract
:Simple Summary
Abstract
1. Introduction
2. A Technical Insight
3. A Role of Exosomes in Cancer: From Preclinical to Clinical Data
4. Exosomes Deliver Enzymatic Activity
5. Exosomes Deliver Nucleic Acids
6. Conclusions
Tumor | Biomarkers | Source | References |
---|---|---|---|
Breast cancer | Breast cancer resistance protein (BCRP) | Plasma | [113] |
Her2 | Plasma Serum | [114,115] | |
Glypican-1 | Serum | [56] | |
Fibronectin | Plasma | [116] | |
Periostin | Plasma | [117] | |
Del-1 | Plasma | [118,119] | |
miR-101, miR-372, and miR-373 | Serum | [84] | |
miR-1246 and miR-21 | Plasma | [85] | |
Colorectal cancer | Hsp60 | Plasma | [38] |
TSAP6/CEA | Plasma | [86] | |
Glypican-1 | Plasma | [28] | |
CEA | Serum | [45,87] | |
CD147 | Serum | [87] | |
Plasma | [89] | ||
let-7a, miR-1229, miR-1246, miR-150, miR-21, miR-223, and miR-23a | Serum | [90] | |
miR-19 | Serum | [91] | |
miR-4772-3p | Serum | [92] | |
miR-21 | Serum | [87] | |
miR-221 | Serum | [94] | |
Esophageal squamous sell sarcinoma | miR-21 | Serum | [95] |
Gastric cancer | GKN1 | Serum | [96] |
TGF-β1 | Plasma | [97] | |
RNA | Bile | [98] | |
miR-423-5p | Serum | [99] | |
Hematological tumors | CD9, CD13, CD19, CD30, CD38, and CD63 | Serum | [100] |
Hepatocellular carcinoma | miR-18a, miR-221, miR-222, and miR-224 | Serum | [101] |
miR-718 | Serum | [102] | |
Laryngeal squamous cell carcinoma | miR-21 and HOTAIR (lncRNA) | Serum | [103] |
Lung cancer | NY-ESO-1 | Plasma | [104] |
miR-125a-5p, miR-145, and miR-146a | Serum | [105] | |
miR-151a-5p, miR-30a-3p, miR-200b-5p, miR-629, miR-100, and miR-154-3p | Plasma | [106] | |
Melanoma | Caveolin-1 | Plasma | [24] |
HSP70 and HSP90 | Plasma | [120] | |
MIA and S100B | Serum | [121] | |
Oral squamous cell carcinoma | CAV-1 | Plasma | [43] |
Ovarian cancer | EpCAM, CD24, and CA-125 | Plasma | [122,123,124] |
TGF-beta1 and MAGE3/6, | Plasma | [125] | |
miR-21, miR-214, miR-200a, miR-200b, miR-200c, miR-203, miR-205, and miR-141 | Serum | [126] | |
miR-21, miR-100, miR-200, miR-320, and miR373 | Serum | [107] | |
Pancreatic cancer | CD44v6, Tspan 8, EpCAM, and CD104 miR-1246 miR-3976 miR-4306 miR-4644 | Serum Urine | [64] |
KRAS P53 mutations | Serum | [71] | |
miR-17-5p and miR-21 | Serum | [108] | |
miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a | Serum | [127] | |
Glypican-1 | Plasma | [109] | |
miR-191, miR-21, and miR-451a | Serum | [110] | |
miR-451a | Plasma | [111] | |
Prostate cancer (PCa) | PSA | Plasma | [44,53] |
Urine | [25] | ||
CA IX | Plasma | [47] | |
Survivin | Plasma | [128] | |
Exosome levels | Plasma | [41] | |
PTEN | Plasma | [129] | |
miR-141 and miR-375 | Serum | [130] | |
miR-1290 and miR-375 | Plasma | [131] | |
miR-141 | Serum | [132] |
NCT Number | Status | Disease | Characteristics | Ref. |
---|---|---|---|---|
NCT03235687 | Active, not reciting | Prostate Cancer | Year: 2017 Population: n = 1000; Age: 50 years and older; Sex: male Phase: Not applicable | [133] |
NCT03974204 | Withdrawn | Breast Cancer Leptomeningeal Metastasis | Year: 2019 Population: n = 0; Age: 18 years and older; Sex: female Phase: Not applicable | [134] |
NCT05286684 | Recruiting | Breast Cancer | Year: 2023 Population: n = 30; Age: 18 years and older; Sex: female Phase: Not applicable | [135] |
NCT04781062 | Active, not recruiting | Breast Cancer | Year: 2021 Population: n = 367; Age: 18 years and older; Sex: female Phase: Not applicable | [136] |
NCT02662621 | Completed | Cancer (Solid Tumors) | Year: 2015 Population: n = 71; Age: 18 years and older; Sex: all Phase: Not applicable | [137] |
NCT04530890 | Recruiting | Breast Cancer Digestive Cancer Gynecologic Cancer Circulating Tumor DNA Exosomes | Year: 2021 Population: n = 1000; Age: 18 years and older; Sex: all Phase: Not applicable | [138] |
NCT04258735 | Recruiting | Metastatic Breast Cancer | Year: 2019 Population: n = 300; Age: 18 years and older; Sex: all Phase: Not applicable | [139] |
NCT04556916 | Recruiting | Prostate Cancer | Year: 2021 Population: n = 320; Age: 40 years and older; Sex: male Phase: Not applicable | [140] |
NCT03711890 | Recruiting | Pancreatic Carcinoma Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary Type | Year: 2019 Population: n = 75; Age: 18 years and older; Sex: all Phase: Not applicable | [141] |
NCT02507583 | Completed | Malignant Glioma Neoplasms | Year: 2015 Population: n = 33; Age: 18 years and older; Sex: all Phase: Phase 1 | [142] |
NCT05218759 | Not yet recruiting | Non-Small Cell Lung Cancer | Year: 2022 Population: n = 30; Age: 18 to 75 years; Sex: all Phase: Not applicable | [143] |
NCT04427475 | Unknown status | NSCLC Patients | Year: 2020 Population: n = 200; Age: 18 years and older; Sex: all Phase: Not applicable | [144] |
NCT04636788 | Unknown status | Pancreas Adenocarcinoma | Year: 2020 Population: n = 102; Age: 18 years and older; Sex: all Phase: Not applicable | [145] |
NCT03542253 | Unknown status | Early Lung Cancer | Year: 2018 Population: n = 80; Age: child, adult, and older adult; Sex: all Phase: not reported | [146] |
NCT04529915 | Active, not recruiting | Lung Cancer | Year: 2020 Population: n = 470; Age: 40 years and older; Sex: all Phase: not reported | [147] |
NCT03821909 | Unknown status | Pancreatic Cancer | Year: 2018 Population: n = 30; Age: 18 to 80 years; Sex: all Phase: not repoted | [148] |
NCT03830619 | Completed | Lung Cancer (Diagnosis) | Year: 2017 Population: n = 1000; Age: 18 to 75 years; Sex: all Phase: not reported | [149] |
NCT04394572 | Completed | Colorectal Cancer | Year: 2021 Population: n = 80; Age: 18 years and older; Sex: all Phase: not reported | [150] |
NCT04155359 | Recruiting | Bladder Cancer | Year: 2020 Population: n = 3000; Age: 45 to 85 years; Sex: all Phase: not reported | [151] |
NCT01344109 | Withdrawn | Breast Neoplasms | Year: 2011 Population: n = 0; Age: 18 years and older; Sex: female Phase: not reported | [152] |
NCT05587114 | Recruiting | Lung Cancer Diagnosis | Year: 2022 Population: n = 150; Age: 40 years and older; Sex: all Phase: not reported | [153] |
NCT05270174 | Not yet recruiting | Explore Whether lncRNA-ElNAT1 in Urine Exosomes Can be Used as a New Target for Preoperative Diagnosis of Lymph Node Metastasis | Year: 2023 Population: n = 75; Age: 18 years and older; Sex: all Phase: not reported | [154] |
NCT03032913 | Completed | Pancreatic Ductal Adenocarcinoma (PDAC) | Year: 2017 Population: n = 52; Age: 18 years and older; Sex: all Phase: not reported | [155] |
NCT02702856 | Completed | Prostate Cancer | Year: 2014 Population: n = 2000; Age: 50 years and older; Sex: male Phase: not reported | [156] |
NCT04523389 | Unknown status | Colorectal Cancer | Year: 2020 Population: n = 172; Age: 18 years and older; Sex: all Phase: not reported | [157] |
NCT03694483 | Suspended | Prostate Cancer | Year: 2018 Population: n = 600; Age: 18 years and older; Sex: male Phase: not reported | [158] |
NCT04661176 | Active, not recruiting | Prostate Cancer | Year: 2020 Population: n = 500; Age: 22 years and older; Sex: male Phase: not reported | [159] |
NCT02393703 | Recruiting | Pancreatic Cancer Benign Pancreatic Disease | Year: 2015 Population: n = 111; Age: 18 years and older; Sex: all Phase: not reported | [160] |
NCT01779583 | Unknown status | Gastric Cancer | Year: 2013 Population: n = 80; Age: 18 years and older; Sex: all Phase: not reported | [161] |
NCT04081194 | Unknown status | New Tumor Diagnostics From Human Plasma Samples | Year: 2016 Population: n = 15; Age: 50 to 90 years; Sex: all Phase: not reported | [162] |
NCT03236688 | Suspended | Metastatic Castrate-Resistant Prostate Cancer | Year: 2016 Population: n = 30; Age: 18 years and older; Sex: male Phase: not reported | [163] |
NCT04629079 | Recruiting | Lung Cancer | Year: 2020 Population: n = 800; Age: 18 years and older; Sex: all Phase: not reported | [164] |
NCT04939324 | Active, not recruiting | Lung Cancer Exosomes Non-Small Cell Lung Cancer | Year: 2021 Population: n = 30; Age: 18 years and older; Sex: all Phase: Not Applicable | [165] |
NCT04288141 | Recruiting | HER2-positive Breast Cancer | Year: 2019 Population: n = 40; Age: 18 years and older; Sex: all Phase: not reported | [166] |
NCT03874559 | Unknown status | Rectal Cancer | Year: 2018 Population: n = 30; Age: 18 years and older; Sex: all Phase: not reported | [167] |
NCT03738319 | Unknown status | High-Grade Serous Carcinoma Ovarian Cancer Exosomes Prognosis Early Diagnosis | Year: 2018 Population: n = 160; Age: 18 years and older; Sex: female Phase: not reported | [168] |
NCT04720599 | Completed | Urologic Cancer | Year: 2020 Population: n = 120; Age: 50 years and older; Sex: male Phase: not reported | [169] |
NCT05101655 | Completed | Osteosarcoma Pulmonary Metastases | Year: 2020 Population: n = 60; Age: 12 to 60 years; Sex: all Phase: not reported | [170] |
NCT04315753 | Unknown status | Lung Cancer | Year: 2018 Population: n = 2000; Age: 55 years and older; Sex: all Phase: not reported | [171] |
NCT03895216 | Completed | Bone Metastases | Year: 2018 Population: n = 34; Age: 18 years and older; Sex: all Phase: not reported | [172] |
NCT04960956 | Terminated | Prostate Cancer Urothelial Carcinoma | Year: 2016 Population: n = 13; Age: 18 years and older; Sex: male Phase: not reported | [173] |
NCT03911999 | Completed | Prostate Cancer | Year: 2018 Population: n = 180; Age: 45 years and older; Sex: male Phase: not reported | [174] |
NCT05572099 | Recruiting | Prostate Cancer | Year: 2018 Population: n = 750; Age: 45 years and older; Sex: male Phase: not reported | [175] |
NCT04323579 | Unknown status | Lung Cancer | Year: 2018 Population: n = 2000; Age: 55 years and older; Sex: all Phase: not reported | [176] |
NCT04357717 | Terminated | Prostate Cancer | Year: 2020 Population: n = 150; Age: 50 years and older; Sex: male Phase: not reported | [177] |
NCT04100811 | Recruiting | Prostate Cancer | Year: 2020 Population: n = 4000; Age: 45 years and older; Sex: male Phase: not reported | [178] |
NCT05463107 | Not yet recruiting | Thyroid Cancer Follicular Thyroid Cancer | Year: 2022 Population: n = 50; Age: 20 to 80 years; Sex: all Phase: not reported | [179] |
NCT04653740 | Recruiting | Advanced Breast Cancer | Year: 2020 Population: n = 25; Age: 18 years and older; Sex: female Phase: Not applicable | [180] |
NCT02147418 | Recruiting | Oropharyngeal Cancer | Year: 2015 Population: n = 30; Age: 18 years and older; Sex: all Phase: Not reported | [181] |
NCT03432806 | Recruiting | Colon Cancer Liver Tumors | Year: 2017 Population: n = 80; Age: 18 years and older; Sex: all Phase: Not reported | [182] |
NCT05397548 | Recruiting | Gastric Cancer | Year: 2022 Population: n = 700; Age: 18 to 80 years; Sex: all Phase: Not reported | [183] |
NCT03811600 | Completed | Sleep Apnea Syndromes, Obstructive Cancer | Year: 2019 Population: n = 90; Age: 18 years and older; Sex: all Phase: not reported | [184] |
NCT03108677 | Active, not recruiting | Lung Metastases Osteosarcoma | Year: 2017 Population: n = 90; Age: 12 to 60 years; Sex: all Phase: not reported | [185] |
NCT04499794 | Recruiting | Untreated Advanced NSCLC Patients FISH-Identified ALK Fusion (Positive or Negative) | Year: 2020 Population: n = 75; Age: 18 years and older; Sex: all Phase: not reported | [186] |
NCT04182893 | Unknown status | Pulmonary Nodules | Year: 2019 Population: n = 400; Age: 18 years and older; Sex: all Phase: not reported | [187] |
NCT02464930 | Unknown status | Barrett’s Esophagus Gastroesophageal Reflux Esophageal Adenocarcinoma | Year: 2015 Population: n = 220; Age: 18 years and older; Sex: all Phase: not reported | [188] |
NCT05625529 | Not yet recruiting | Pancreas Cancer Exosomes Extracellular Vesicles Pancreatic Neoplasms | Year: 2022 Population: n = 1000; Age: 18 years and older; Sex: all Phase: not reported | [189] |
NCT03581435 | Unknown status | Proteinosis Gallbladder Carcinoma | Year: 2018 Population: n = 50; Age: 18 years and older; Sex: all Phase: not reported | [190] |
NCT03102268 | Unknown status | Cholangiocarcinoma Benign Biliary Stricture | Year: 2017 Population: n = 80; Age: 18 years and older; Sex: all Phase: not reported | [191] |
NCT05705583 | Recruiting | Renal Cell Carcinoma | Year: 2023 Population: n = 100; Age: 18 years and older; Sex: all Phase: not reported | [192] |
NCT03334708 | Recruiting | Pancreatic Cancer Pancreatic Diseases Pancreatitis Pancreatic Cyst | Year: 2017 Population: n = 700; Age: 18 years and older; Sex: all Phase: not reported | [193] |
NCT03800121 | Recruiting | Sarcoma | Year: 2018 Population: n = 30; Age: 18 years and older; Sex: all Phase: not reported | [194] |
NCT05744076 | Active, not recruiting | Melanoma | Year: 2019 Population: n = 150; Age: 18 years and older; Sex: all Phase: not reported | [195] |
NCT04053855 | Recruiting | Clear Cell Renal Cell Carcinoma | Year: 2020 Population: n = 100; Age: 18 years and older; Sex: all Phase: not reported | [196] |
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Logozzi, M.; Orefice, N.S.; Di Raimo, R.; Mizzoni, D.; Fais, S. The Importance of Detecting, Quantifying, and Characterizing Exosomes as a New Diagnostic/Prognostic Approach for Tumor Patients. Cancers 2023, 15, 2878. https://doi.org/10.3390/cancers15112878
Logozzi M, Orefice NS, Di Raimo R, Mizzoni D, Fais S. The Importance of Detecting, Quantifying, and Characterizing Exosomes as a New Diagnostic/Prognostic Approach for Tumor Patients. Cancers. 2023; 15(11):2878. https://doi.org/10.3390/cancers15112878
Chicago/Turabian StyleLogozzi, Mariantonia, Nicola Salvatore Orefice, Rossella Di Raimo, Davide Mizzoni, and Stefano Fais. 2023. "The Importance of Detecting, Quantifying, and Characterizing Exosomes as a New Diagnostic/Prognostic Approach for Tumor Patients" Cancers 15, no. 11: 2878. https://doi.org/10.3390/cancers15112878