Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC)
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients and Demographics
2.2. PET/MRI Imaging
2.3. Image Analysis
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
PET/MRI | Positron Emission Tomography/Magnetic Resonance Imaging |
SUV | Standardized Uptake Value |
MTV | Metabolic Tumor Volume |
TLG | Metabolic Tumor Volume |
CRT | Chemo-Radiotherapy |
HCC | Head and Neck Cancer |
FDG | Fluorodeoxyglucose |
AJCC | American Joint Committee on Cancer |
(G) | Grade |
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Number of Patients | 71 |
---|---|
Mean Age (y) | (61.6 ± 0.8) |
Men | 49 (69.0%) |
Women | 22 (31.0%) |
Histologic Grade | |
Grade 1 | 12 (16.9%) |
Grade 2 | 41 (57.7%) |
Grade 3 | 18 (20.4%) |
Localization | |
Pharyngeal | 32 (45.1%) |
Laryngeal | 15 (21.1%) |
Oral | 22 (33.8%) |
T category | |
T1 | 4 (5.6%) |
T2 | 19 (26.8%) |
T3 | 26 (36.6%) |
T4 | 22 (31.0%) |
N category | |
N0 | 10 (14.1%) |
N1 | 9 (12.7%) |
N2 | 45(63.4%) |
N3 | 7 (9.9%) |
M Category | |
M0 | 63 (88.7%) |
M1 | 8 (11.3%) |
N groups | |
N+ | 61 (85.9%) |
N− | 10 (14.1%) |
Parameter | ADC | SUVmax | TLG | MTV | Tumor Size | |
---|---|---|---|---|---|---|
ADC | Spearman (rho) | −0.184 | −0.182 | −0.037 | −0.088 | |
Sig. (2-tailed) | −0.125 | 0.129 | 0.756 | 0.464 | ||
SUVmax | Spearman (rho) | 0.456 * | ||||
Sig. (2-tailed) | 0.000 | |||||
TLG | Spearman (rho) | 0.794 * | ||||
Sig. (2-tailed) | 0.000 | |||||
MTV | Spearman (rho) | 0.739 * | ||||
Sig. (2-tailed) | 0.000 |
Grouping | SUVmax | TLG | MTV | ADC |
---|---|---|---|---|
SEX | p = 0.314 | p = 0.522 | p = 0.784 | p = 0.897 |
T stages | p = 0.267 | p =0.006 | p= 0.001 | p = 0.880 |
N stages | p =0.023 | p =0.033 | p = 0.605 | p = 0.092 |
M stages | p = 0.283 | p = 0.785 | p = 0.913 | p = 0.347 |
Grades | p = 0.233 | p = 0.310 | p = 0.713 | p =0.050 |
Localization | p = 0.389 | p = 0.128 | p = 0.367 | p = 0.270 |
Prognostic Factors | B | T | p Value |
---|---|---|---|
SUVmax | |||
Tumor size | 0.409 | 3.333 | 0.001 * |
T stages | N/A | N/A | N/A |
N stages | 0.227 | 1.995 | 0.022 * |
TLG | |||
Tumor size | 0.767 | 8.988 | 0.000 * |
T stages | −0.050 | −0.598 | 0.552 |
N stages | 0.119 | 1.500 | 0.138 |
MTV | |||
Tumor size | 0.662 | 6.857 | 0.000 * |
T stages | 0.140 | 1.473 | 0.146 |
N stages | N/A | N/A | N/A |
ADC | |||
N stages | 0.043 | 2.042 | 0.069 |
Tumor grades | −0.021 | −1.846 | 0.045 * |
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Freihat, O.; Zoltán, T.; Pinter, T.; Kedves, A.; Sipos, D.; Repa, I.; Kovács, Á.; Zsolt, C. Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC). Cancers 2022, 14, 847. https://doi.org/10.3390/cancers14030847
Freihat O, Zoltán T, Pinter T, Kedves A, Sipos D, Repa I, Kovács Á, Zsolt C. Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC). Cancers. 2022; 14(3):847. https://doi.org/10.3390/cancers14030847
Chicago/Turabian StyleFreihat, Omar, Tóth Zoltán, Tamas Pinter, András Kedves, Dávid Sipos, Imre Repa, Árpád Kovács, and Cselik Zsolt. 2022. "Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC)" Cancers 14, no. 3: 847. https://doi.org/10.3390/cancers14030847