Reproductive and Endocrine Outcomes in a Cohort of Danish Women following Auto-Transplantation of Frozen/Thawed Ovarian Tissue from a Single Center
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
Ethics
3. Results
3.1. Pregnancy and Live Birth Rates following OTT
3.2. Fertility Treatment
3.3. Endocrine Function of the Grafted Tissue in Women with POI
3.4. Repeated Transplantations
3.5. Relapse of Malignancy after OTT
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Women, n = 40 (%) | Pregnant, n = 22 (%) | Non-Pregnant, n = 17 (%) | p-Value | |
---|---|---|---|---|
Age at OTC a, mean (SD) | 28.9 (5.5) | 28.9 (5.0) | 28.7 (6.2) | 0.94 |
15–19 | 3 (7.5) | 2 (9) | 1 (6) | |
20–24 | 6 (15.0) | 2 (9) | 4 (24) | |
25–29 | 9 (22.5) | 5 (23) | 4 (24) | |
30–34 | 15 (37.5) | 11 (50) | 4 (24) | |
35–39 | 7 (17.5) | 2 (9) | 4 (24) | |
AMH at OTC a, mean (SD) (Median, IQR) | 19.7 (19.9) (15.0, 14.8) | 25.8 (24.8) (19.0, 10.0) | 10.3 (6.4) (7.2, 7.1) | 0.14 |
AFC at OTC a, mean (SD) (Median, IQR) | 15.8 (14.2) (12.0, 10.0) | 20.0 (16.7) (16.0, 18.0) | 8.7 (4.7) (10.0, 8.0) | 0.04 |
Diagnosis at OTC a | ||||
Breast cancer | 19 (48) | 11 (50) | 8 (47) | |
Leukemia (CML) | 1 (3) | 0 (0) | 1 (6) | |
Hodgkins disease | 7 (18) | 4 (18) | 3 (18) | |
Non-Hodgkins lymphoma | 4 (10) | 2 (9) | 2 (12) | |
Other malignancy | 3 (8) | 1 (5) | 2 (12) | |
Benign disease | 6 (15) | 4 (18) | 1 (6) | |
Previous deliveries | 6 (15) | 4 (18) | 2 (12) | |
Pelvic radiation | 1.0 | |||
Yes | 4 (10) | 2 (9) | 2 (12) | |
No | 36 (90) | 20 (91) | 15 (88) | |
Age at first OTT | 33.7 (5.5) | 28.9 (5.0) | 28.4 (6.2) | 0.76 |
Time to first OTT (years) | 4.2 (2.9) | 3.6 (1.2) | 5.3 (4.0) | |
Ovarian function before first OTT | 0.12 | |||
POI | 19 (48) | 9 (41) | 9 (53) | |
Unstable ovarian function | 10 (25) | 4 (18) | 6 (35) | |
Ongoing ovarian function | 11 (28) | 9 (41) | 2 (12) | |
Number of OTTs | ||||
1 | 40 (100) | 16 (73) | 11 (65) | |
2 | 12 (30) | 5 (23) | 6 (35) | |
3 | 1 (3) | 1 (5) | 0 (0) | |
ART after OTT (from 39 women) | ||||
Yes | 30 (77) | 11 (50) | 17 (100) | |
No b | 9 (23) | 11 (50) | 0 (0) |
Women with Pregnancy Wish | Pregnancies (n = 29) | Deliveries (n = 20) | |||
---|---|---|---|---|---|
n | Women, n | Rate % (95% CI) | Women, n | Rate % (95% CI) | |
Overall | 39 | 22 | 56% (39.6, 72.2) | 16 | 41% (25.6, 57.9) |
Method of Conception | Women with a Pregnancy Wish n | Women who Conceived n (%) | Women who Gave Birth n (%) | Pregnancies n (%) | Deliveries n (%) | Pregnancy Loss n (%) |
---|---|---|---|---|---|---|
ART | 30 | 11 (50) | 6 (38) | 14 (48) | 8 (40) | 6 (43) |
Natural | 11 | 11 (50) | 10 (63) | 15 (52) | 12 (60) | 3 (20) |
Cycles, n | Pregnancy Outcome, n | Pr Transfer (%) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
ALL | Cancelled | Transfer | Ectopic | Early Miscarriage | Bio-Chemical | Deliveries | TOTAL | Clinical PR | LBR | |
IVF/ICSI | 121 | 77 | 44 | 1 | 1 | 3 | 6 | 11 | 18.2% | 13.6% |
FET | 6 | 1 | 5 | 0 | 0 | 1 | 2 | 3 | 40.0% | 40.0% |
TOTAL | 127 | 78 | 49 | 1 | 1 | 4 | 8 | 14 | 20.4% | 16.4% |
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Colmorn, L.B.; Pedersen, A.T.; Larsen, E.C.; Hansen, A.S.; Rosendahl, M.; Andersen, C.Y.; Kristensen, S.G.; Macklon, K.T. Reproductive and Endocrine Outcomes in a Cohort of Danish Women following Auto-Transplantation of Frozen/Thawed Ovarian Tissue from a Single Center. Cancers 2022, 14, 5873. https://doi.org/10.3390/cancers14235873
Colmorn LB, Pedersen AT, Larsen EC, Hansen AS, Rosendahl M, Andersen CY, Kristensen SG, Macklon KT. Reproductive and Endocrine Outcomes in a Cohort of Danish Women following Auto-Transplantation of Frozen/Thawed Ovarian Tissue from a Single Center. Cancers. 2022; 14(23):5873. https://doi.org/10.3390/cancers14235873
Chicago/Turabian StyleColmorn, Lotte B., Anette T. Pedersen, Elisabeth C. Larsen, Alexandra S. Hansen, Mikkel Rosendahl, Claus Yding Andersen, Stine G. Kristensen, and Kirsten T. Macklon. 2022. "Reproductive and Endocrine Outcomes in a Cohort of Danish Women following Auto-Transplantation of Frozen/Thawed Ovarian Tissue from a Single Center" Cancers 14, no. 23: 5873. https://doi.org/10.3390/cancers14235873