Frequency of Positive Familial Criteria in Patients with Adenocarcinoma of the Esophageal-Gastric Junction and Stomach: First Prospective Data in a Caucasian Cohort †
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
3. Results
3.1. Basic Patient Characteristics
3.2. Comparison with Data from the Clinical Cancer Registry for Brandenburg and Berlin
3.3. Familial Criteria for HDGC
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Total | AEG | Gastric Cancer | p | ||||
---|---|---|---|---|---|---|---|
n | (%) | n | (%) | n | (%) | ||
Sex | |||||||
Female | 56 | (36.6) | 14 | (23.0) | 42 | (45.7) | 0.004 |
Male | 97 | (63.4) | 47 | (77.0) | 50 | (54.3) | |
Age | |||||||
<50 | 20 | (13.1) | 5 | (8.2) | 15 | (16.3) | 0.350 |
≥50 | 133 | (86.9) | 56 | (91.8) | 77 | (83.7) | |
Localization | |||||||
AEG I | 29 | (19.1) | 29 | (47.5) | X | x | |
AEG II | 32 | (21.1) | 32 | (52.5) | X | ||
Cardia | 13 | (8.6) | X | 13 | (14.1) | ||
Fundus | 1 | (0.7) | X | 1 | (1.1) | ||
Corpus | 42 | (27.6) | X | 43 | (46.7) | ||
Antrum | 35 | (23.0) | X | 35 | (38.0) | ||
UICC Stage | |||||||
I | 14 | (9.2) | 6 | (9.8) | 8 | (8.7) | 0.860 |
II | 23 | (15) | 7 | (11.5) | 16 | (17.4) | |
III | 31 | (20.3) | 14 | (23.0) | 17 | (18.5) | |
IV | 59 | (38.6) | 24 | (39.3) | 35 | (38.0) | |
unspecified | 26 | (17.0) | 10 | (16.4) | 16 | (17.4) | |
Grading | |||||||
G1 | 8 | (5.2) | 4 | (6.6) | 4 | (4.3) | 0.503 |
G2 | 51 | (33.3) | 24 | (39.3) | 27 | (29.3) | |
G3 | 86 | (56.2) | 30 | (49.2) | 56 | (60.9) | |
unspecified | 8 | (5.2 | 3 | (4.3 | 8 | (5.4 | |
Lauren | |||||||
Intestinal | 77 | (50.3) | 38 | (62.3) | 39 | (42.4) | 0.008 |
Mixed | 19 | (12.4) | 4 | (6.6) | 15 | (16.3) | |
Diffuse | 48 | (31.4) | 13 | (21.3) | 35 | (38.0) | |
unspecified | 9 | (5.9) | 4 | (6.6) | 3 | (3.3) | |
Incidence of cancer in family | |||||||
Yes | 88 | (57.5) | 20 | (32.8) | 31 | (33.7) | 0.629 |
No | 51 | (33.3) | 37 | (60.7) | 51 | (55.4) | |
Unknown | 14 | (9.2) | 4 | (6.6) | 10 | (10.9) | |
History of Smoking | |||||||
Yes | 98 | (64.1) | 41 | (67.2) | 57 | (62.0) | 0.798 |
No | 52 | (34.0) | 19 | (31.1) | 33 | (35.9) | |
Unknown | 3 | (2.0) | 1 | (1.6) | 2 | (2.2) | |
BMI | |||||||
<25 | 72 | (47.1) | 22 | (36.1) | 50 | (54.3) | 0.39 |
≥25 | 71 | (46.4) | 36 | (59.0) | 35 | (38.0) | |
Unknown | 10 | (6.5) | 3 | (4.9) | 7 | (7.6) | |
Diabetes | |||||||
Yes | 33 | (21.6) | 15 | (24.6) | 18 | (19.6) | 0.558 |
No | 119 | (77.8) | 46 | (75.4) | 73 | (79.3) | |
Unspecified | 1 | (0.7) | 0 | (0.0) | 1 | (1.1) | |
Helicobacter pylori History | |||||||
Yes | 29 | (19.0) | 3 | (4.9) | 29 | (31.5) | 0.001 |
No | 51 | (33.3) | 22 | (36.1) | 26 | (28.3) | |
Unknown | 73 | (47.7) | 36 | (59.0) | 37 | (40.2) |
(A) | |||||||||
HDGC 2015 (van der Post) | HDGC 2020 (Blair) | ||||||||
Family Criteria | |||||||||
≥2 cases of gastric cancer in family regardless of age, with at least one DGC | |||||||||
≥1 case of DGC at any age, and ≥1 case of lobular breast cancer <50 years, in different family members | ≥1 case of DGC at any age, and ≥1 case of lobular breast cancer <70 years, in different family members | ||||||||
≥2 cases of lobular breast cancer in family members <50 years | |||||||||
Individual Criteria | |||||||||
DGC <40 years | DGC <50 years | ||||||||
Gastric in situ signet ring cells or pagetoid spread of signet ring cells | Gastric in situ signet ring cells or pagetoid spread of signet ring cells in individuals <50 years | ||||||||
DGC at any age in individuals with a personal or family history (1st degree) of cleft lip or cleft palate | |||||||||
History of DGC and lobular breast cancer, one diagnosed <50 years | History of DGC and lobular breast cancer, both diagnosed <70 years | ||||||||
Bilateral lobular breast cancer, diagnosed <50 years | Bilateral lobular breast cancer, diagnosed <70 years | ||||||||
FIGC 2015 (van der Post) | FIGC 2020 (Blair) | ||||||||
Family Criteria | |||||||||
≥2 cases of gastric cancer in family regardless of age | |||||||||
≥1 case of gastric cancer at any age, and ≥1 case of lobular breast cancer <50 years, in different family members | ≥1 case of gastric cancer at any age, and ≥1 case of lobular breast cancer <70 years, in different family members | ||||||||
Individual Criteria | |||||||||
Gastric Cancer <40 years | Gastric Cancer <50 years | ||||||||
GC at any age in individuals with a personal or family history (1st degree) of cleft lip or cleft palate | |||||||||
History of gastric Cancer and lobular breast cancer, one diagnosed <50 years | History of gastric cancer and lobular breast cancer, both diagnosed <70 years | ||||||||
(B) | |||||||||
AEG (n = 61) | GC (n = 92) | AEG (n = 61) | GC (n = 92) | ||||||
HDGC 2015 (van der Post) | HDGC 2020 (Blair) | ||||||||
Family Criteria | n | % | n | % | n | % | n | % | Family Criteria |
≥2 cases of gastric cancer in family regardless of age, with at least one DGC | - | - | 5 | 5.4 | - | - | 5 | 5.4 | ≥2 cases of gastric cancer in family regardless of age, with at least one DGC |
≥1 case of DGC at any age, and ≥1 case of lobular breast cancer <50 years, in different family members | - | - | - | - | −(2) * | −(3.2) * | −(1) * | −(1.1) * | ≥1 case of DGC at any age, and ≥1 case of lobular breast cancer <70 years, in different family members |
Individual Criteria | n | % | n | % | n | % | n | % | Individual Criteria |
DGC <40 years | 3 | 4.9 | 3 | 3.3 | 4 | 6.5 | 7 | 7.6 | DGC <50 years |
History of DGC and lobular breast cancer, one diagnosed <50 years | - | - | 1 | 1.1 | - | - | 2 | 2.2 | History of DGC and lobular breast cancer, both diagnosed <70 years |
Total | 3 | 4.9 | 9 | 9.8 | 4 (6) | 6.5 (9.8) | 14 (15) | 15.2 (16.3) | Total |
FIGC 2015 (van der Post) | FIGC 2020 (Blair) | ||||||||
Family Criteria | n | % | n | % | n | % | n | % | Family Criteria |
≥2 cases of gastric cancer in family regardless of age | 2 | 3.3 | 6 | 6.5 | 2 | 3.3 | 6 | 6.5 | ≥2 cases of gastric cancer in family regardless of age |
≥1 case of gastric cancer at any age, and ≥1 case of lobular breast cancer <50 years, in different family members | - | - | −(2) | −(2.2) | −(4) | −(6) | −(5) | −(5.4) | ≥1 case of gastric cancer at any age, and ≥1 case of lobular breast cancer <70 years, in different family members |
Individual Criteria | n | % | n | % | n | % | n | % | Individual Criteria |
Gastric cancer <40 years | - | - | 2 | 2.2 | 2 | 3.3 | 7 | 7.6 | Gastric cancer <50 years |
Total | 2 | 3.3 | 8 (10) | 8.7 (10.9) | 4 (8) | 6.6 (13.0) | 13 (18) | 14.1 (19.6) | Total |
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Schölzchen, J.; Treese, C.; Thuss-Patience, P.; Mrózek, A.; Rau, B.; Seeliger, H.; Hartmann, D.; Estevéz-Schwarz, L.; Siegmund, B.; Horn, D.; et al. Frequency of Positive Familial Criteria in Patients with Adenocarcinoma of the Esophageal-Gastric Junction and Stomach: First Prospective Data in a Caucasian Cohort. Cancers 2022, 14, 3590. https://doi.org/10.3390/cancers14153590
Schölzchen J, Treese C, Thuss-Patience P, Mrózek A, Rau B, Seeliger H, Hartmann D, Estevéz-Schwarz L, Siegmund B, Horn D, et al. Frequency of Positive Familial Criteria in Patients with Adenocarcinoma of the Esophageal-Gastric Junction and Stomach: First Prospective Data in a Caucasian Cohort. Cancers. 2022; 14(15):3590. https://doi.org/10.3390/cancers14153590
Chicago/Turabian StyleSchölzchen, Jan, Christoph Treese, Peter Thuss-Patience, Alicja Mrózek, Beate Rau, Hendrik Seeliger, Dirk Hartmann, Lope Estevéz-Schwarz, Britta Siegmund, Denise Horn, and et al. 2022. "Frequency of Positive Familial Criteria in Patients with Adenocarcinoma of the Esophageal-Gastric Junction and Stomach: First Prospective Data in a Caucasian Cohort" Cancers 14, no. 15: 3590. https://doi.org/10.3390/cancers14153590