Primary and Acquired Resistance against Immune Check Inhibitors in Non-Small Cell Lung Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Primary Resistance against ICIs in NSCLC
2.1. Step 1. Lack of Neo-Antigen Due to Low TMB
2.2. Step 2. Disruption of Neo-Antigens Presentation
2.3. Step 3. Impaired Priming or Activation in Effector T Cells
2.4. Step 4. Inhibition of T Cell Trafficking
2.5. Step 5. Prevention of T-Cell Infiltration
2.6. Step 6. Incompetence in the Recognition of Cancer Cells by T Cells
2.7. Step 7. Inability of T Cell to Eliminate Tumor Cells
2.7.1. Driver Genes Mutation
2.7.2. Inactivation of Tumor Suppressor Genes
2.7.3. Dysfunction in Interferon-γ Pathway
2.7.4. Immune-Suppressive Cytokines
2.7.5. Upregulation of Alternative Co-Inhibitory Immune Checkpoint Molecules
2.7.6. Immune-Suppressive Cells
2.7.7. Altered Metabolism through Indoleamine 2,3-Dioxygenase (IDO)
2.7.8. Regulation of Immune Checkpoints through Epigenetic Modifications
3. Acquired Resistance in NSCLC
4. Future Direction
Author Contributions
Funding
Conflicts of Interest
References
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Sun, Q.; Wei, X.; Wang, Z.; Zhu, Y.; Zhao, W.; Dong, Y. Primary and Acquired Resistance against Immune Check Inhibitors in Non-Small Cell Lung Cancer. Cancers 2022, 14, 3294. https://doi.org/10.3390/cancers14143294
Sun Q, Wei X, Wang Z, Zhu Y, Zhao W, Dong Y. Primary and Acquired Resistance against Immune Check Inhibitors in Non-Small Cell Lung Cancer. Cancers. 2022; 14(14):3294. https://doi.org/10.3390/cancers14143294
Chicago/Turabian StyleSun, Qinying, Xiangzhen Wei, Zhonglin Wang, Yan Zhu, Weiying Zhao, and Yuchao Dong. 2022. "Primary and Acquired Resistance against Immune Check Inhibitors in Non-Small Cell Lung Cancer" Cancers 14, no. 14: 3294. https://doi.org/10.3390/cancers14143294